Kao Corporation

Hirohisa Fujihara

Kentaro Kumihashi

Tomohiro Shirai

Nanae Mugita

Kazuki Kinoshita

Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein Rand Reach independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, Rrepresents an alkyl group having 1 to 6 carbon atoms, Rrepresents a hydrogen atom, a methyl group or an ethyl group, and a double line composed of a dotted line and a solid line represents a single bond or a double bond. 

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Cincinnati, OH, United States of America

Hirohisa Fujihara