Denki Kagaku Kogyo Kabushiki Kaisha

Agro-kanesho Co., Ltd.

Hirohiko Kobayashi

Shinobu Iriuchijima

Takeshi Oda

Hiroshi Tabata

Shunnosuke Watanabe

Masayuki Shinoyama

Kyoji Aoki

Yoshifumi Nosaka

Takahito Masuda

Derivatives of benzoisothiazole oxime which exhibit marked effect when used in plant protection agents for control of fungi and bacteria. They are of particular utility for the prevention of rice blast. The derivatives of benzothiazole oxime, according to this invention, are represented by the following general formula (I): ##STR1## wherein R.sub.1 is an alkyl group, and R.sub.2 is an alkyl, alkenyl, alkoxyalkyl or alkoxycarbonyl group, where R.sub.1 and R.sub.2 may be coupled together to form an alkylene chain.

Benzoisothiazole oximes which are plant protection agents for control of

A process for producing oxiracetam (4-hydroxy-2-oxo-1-pyrrolidineacetamide) useful as an agent for improving brain metabolism, under mild conditions and in a single process is provided, this process comprises reacting glycinamide with a butyric acid ester expressed by the formula ##STR1## wherein A represents a halogen atom or an epoxy group, B represents hydroxyl group, but when A is an epoxy group, A and B together form an epoxy group, and R represents an alkyl group.

Process for producing oxiracetam

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Yamato, Japan

Hirohiko Kobayashi