Mitsui Chemicals, Inc.

Mitsui Toatsu Chemicals, Incorporated

Hiroharu Tanikawa

Hironori Komatsu

Hitoshi Shimotori

Hideo Kawashima

Katsutoshi Ishikawa

Toshiyuki Kouno

Tsutomu Ishii

Ryuichi Mita

Nobuyuki Fukazawa

Yukihiro Yoshikawa

Katsutoshi Tsuchiya

Yuji Yanase

Toshiaki Kuwatsuka

Hiroki Ishibashi

Naofumi Tomura

Yoshiro Kanemoto

Kunihiko Morizane

Takeshi Sekino

Sunao Maeda

Yuji Yanese

This invention provides a method for efficiently purifying 5'-protected thymidines which cannot be efficiently purified by the prior art. Impurities can be separated by obtaining crystals including a carbonyl-containing solvent to provide a highly pure 5&#x2032;-protected thymidine. Thus, this invention allows 5&#x2032;-protected thymidines, which cannot be purified in an industrial scale by the prior art, to be easily provided with a high purity in a large scale.

Method for purifying 5' -protected thymidines and novel derivatives thereof

An efficient method for producing cytidine derivatives that took away the previous drawbacks by efficiently synthesizing cytidine derivatives by utilizing a tertiary amine can be provided.

Process for the preparation of cytidine derivatives

Application of a rice blast control agent containing an isothiazolecarboxylic acid derivative of the below-described formula, which shows excellent activity against rice blast (Pyricularia oryzae) in rice cultivation, to the water surface of a paddy rice field results in the absorption of the derivative through roots of rice plants, so that the resistance of the rice plants can be enhanced. ##STR1## wherein R.sup.1 and R.sup.2 independently mean a hydrogen or halogen atom or a particular group, and Y stands for an OR.sub.3 group (R.sup.3 being a hydrogen or alkali metal atom or a particular group), an NHR.sup.4 group (R.sup.4 being a hydrogen atom or a particular group), or a morpholino group.

Isothiazolecarboxylic acid derivatives, rice blast control agents

Pyrimidinyloxy(thio)quinoline derivatives represented by the formula (I) which exhibit an excellent controlling effect for plant diseases and are also safe for crop plants, preparation processes of the derivatives, and agri-horticultural fungicides comprising the derivatives as an active ingredient, are disclosed. ##STR1## In the formula (I), X is an oxygen atom or sulfur atom, Y is a hydrogen atom or halogen atom, Z is a hydrogen atom or methyl, R.sup.1 and R.sup.2 are methoxy or methyl, and n is an integer of 1 or 2.

Pyrimidinyloxy(thio)quinoline derivative, and agri-horticultural

Growing community of inventors

Mobara, Japan

Hiroharu Tanikawa