Other

Sumitomo Electric Industries, Limited

Osaka University

Toray Industries, Inc.

Sansha Electric Manufacturing Company, Limited

Hitachi Plant Engineering Construction Co., Ltd.

Inoue Kinzoku Kogyo Co., Ltd.

Sumitomo Rubber Industries Limited

Yamagata University

Ijunkai

Cancerstem Tech Inc.

Hirofumi Yamamoto

Masaki Mori

Yuichiro Doki

Taro Nishiguchi

Yu Saitoh

Kazuaki Nakane

Xin Wu

Masayuki Kojima

Kazuhiko Noto

Naomichi Mori

Susumu Takahashi

Haruhiro Iida

Yasushi Funakoshi

Yoshikazu Nishimura

Hitoshi Kawaziri

Khoji Ogata

Takeyoshi Uchino

Tomoyuki Ichikawa

Toru Hiyoshi

Yasuhisa Minagawa

Tsutomu Hori

Kyoko Okita

Tsubasa Honke

Masaru Tanaka

Hiroyuki Nakanishi

Toshihiro Akaike

Takashi Hoshiba

Takaya Miyase

Shinji Matsukawa

Haruka Emura

Hiroyuki Kurokawa

Yoshinosuke Hamada

Mizuho Nishio

Junichi Nishimura

Naotsugu Haraguchi

Naomasa Kawaguchi

Noriyuki Tomiyama

Osamu Honda

Masahiro Yanagawa

Takayuki Yoshimiya

Sachiko Nankumo

Yasuyoshi Tsutsumi

Shuji Akai

Hodaka Numasaki

Shoichi Tomohisa

Masahiko Koizumi

Susumu Tanaka

Kiyoshi Akazawa

Shinnosuke Tomita

Mikihiko Kogo

The disclosed feature makes it possible to accurately determine a change that has occurred in a tissue. The feature includes: a binarizing section () that generates, from an image to be analyzed, a plurality of binarized images having respective binarization reference values different from each other; a Betti number calculating section () that calculates, for each of the plurality of binarized images, a one-dimensional Betti number indicating the number of hole-shaped regions each of which is surrounded by pixels each having a first pixel value obtained by binarization and is constituted by pixels each having a second pixel value obtained by binarization; and a determining section () that determines a change that has occurred in the tissue, based on a binarization reference value and a one-dimensional Betti number in a binarized image in which the one-dimensional Betti number is maximized.

Image analysis method, image analysis device, image analysis system, control program, and recording medium

The present invention provides a safe and effective DDS technique that realizes higher accumulation in lesions and reduced accumulation in normal organs including the liver, and thus can afford sufficient therapeutic effects with smaller amounts of drugs. Specifically, a composition containing carbonate apatite particles loaded with a drug, wherein the particles have an average particle size of larger than 500 nm and not more than 1000 nm, primary particles are formed in the presence of a polyethylene glycol (PEG) derivative having one or more carboxylic acids or derivatives thereof or salts thereof at the ends thereof, and the PEG derivative is taken up in the primary particles, is provided.

Drug delivery composition, method for producing same and use thereof

By analyzing an image of a cell sample, whether a cell shown in the image is cancerous or not, the type of cancer, etc. are objectively and appropriately determined. An image analyzing device () includes: a binarizing section () which carries out a binarizing process a plurality of times with respect to a single captured image so as to generate a plurality of binarized images, the binarizing section carrying out the binarizing process each time the binarizing section varies a binarization reference value; a Betti number calculating section () which calculates a region number, which indicates the number of hole-shaped regions, with respect to each of the plurality of binarized images which have been generated; and a cancer determining section () which determines a type of cancer occurring in a cell included in tissue, on the basis of the binarization reference value which has been applied at a time of generation of one of the plurality of binarized images with respect to which one the region number has a given value.

Image analysis method, storage medium, image analysis device, and image analysis system

A silicon carbide epitaxial wafer includes a single crystal silicon carbide substrate of 4H polytype having a major surface thereof inclined at an angle &#x3b8; to a {0001} plane toward a &#x3c;11-20&#x3e; direction, and a silicon carbide epitaxial layer of a thickness t formed on the major surface, wherein a diameter of the single crystal silicon carbide substrate is greater than or equal to 150 mm, wherein the angle &#x3b8; exceeds 0&#xb0;, and is less than or equal to 6&#xb0;, wherein one or more pairs of a screw dislocation pit and a diagonal line defect situated at a distance of t/tan&#x3b8; from the pit are present in a surface of the silicon carbide epitaxial layer, and wherein a density of the pairs of a pit and a diagonal line defect is less than or equal to 2 pairs/cm2.

Silicon carbide epitaxial wafer

The purpose of the present invention is to provide a nucleic acid medication for cancer treatment, the medication being capable of suppressing the growth of cancer stem cells and thus effectively treating cancer. hsa-miR-136-5p, hsa-miR-3065-3p, hsa-miR-4727-5p, hsa-miR-378g, hsa-miR-181a-5p, hsa-miR-362-5p, and hsa-miR-608 have remarkably excellent growth inhibitory action on cancer stem cells and are thus useful as a nucleic acid medication for the treatment of various cancers.

Cancer stem cell growth inhibitor using miRNA

In order to assess, with high accuracy, a degree of a change having occurred in a structure, the present invention includes: a Betti number calculating section () configured to (I) generate, with respect to a single captured image obtained by capturing an image of a structure, a plurality of binarized images having respective binarization reference values different from each other and (II) calculate, for each of the plurality of binarized images, a first characteristic numerical value indicative of the number of connected regions each of which is obtained by connecting pixels each having one of pixel values obtained by binarization; and a prediction score determining section () configured to determine, in accordance with a result of a comparison, information on a change having occurred in the structure, the comparison having been made between (i) a pattern indicative of a relationship between (a) the respective binarization reference values and (b) the first characteristic numerical value and (ii) a predetermined reference pattern.

Image analysis method, image analysis device, image analysis system, and storage medium

The purpose of the present invention is to provide a therapeutic agent which is for inflammatory bowel disease and exhibits superior prophylactic or therapeutic effects on inflammatory bowel disease by using miR-29a and/or miR-29b. The prophylactic or therapeutic agent for inflammatory bowel disease comprises composite particles in which miR-29a and/or miR-29b is/are carried on carbonate apatite particles, and said agent is administered systemically.

Prophylactic or therapeutic agent for inflammatory bowel disease

The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM) and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: subjecting sampled blood or biological fluid to enrichment; and capturing specific cells therefrom onto a hydrophilic polymer layer in a flow field.

Method for capturing specific cells

The present invention provides an agent for promoting skeletal muscle injury repair which agent comprises at least one peptide selected from the following (1) to (4):

Agent for promoting skeletal muscle injury repair

A semiconductor stack includes a substrate made of silicon carbide, and an epi layer disposed on the substrate and made of silicon carbide. An epi principal surface, which is a principal surface opposite to the substrate, of the epi layer is a carbon surface having an off angle of 4&#xb0; or smaller relative to a c-plane. In the epi principal surface, a plurality of first recessed portions having a rectangular circumferential shape in a planar view is formed. Density of a second recessed portion that is formed in the first recessed portions and is a recessed portion deeper than the first recessed portions is lower than or equal to 10 cmin the epi principal surface.

Semiconductor stack

A semiconductor stack includes a substrate made of silicon carbide, and an epi layer disposed on the substrate and made of silicon carbide. An epi principal surface, which is a principal surface opposite to the substrate, of the epi layer is a carbon surface having an off angle of 4&#xb0; or smaller relative to a c-plane. In the epi principal surface, a plurality of first recessed portions having a rectangular circumferential shape in a planar view is formed. Density of a second recessed potion that is formed in the first recessed portions and is a recessed portion deeper than the first recessed portions is lower than or equal to 10 cmin the epi principal surface.

A semiconductor stack includes a substrate made of silicon carbide, and an epi layer disposed on the substrate and made of silicon carbide. An epi principal surface, which is a principal surface opposite to the substrate, of the epi layer is a carbon surface having an off angle of 4&#xb0; or smaller relative to a c-plane. In the epi principal surface, a plurality of first recessed portions having a rectangular circumferential shape in a planar view is famed. Density of a second recessed portion that is formed in the first recessed portions and is a recessed portion deeper than the first recessed portions is lower than or equal to 10 cmin the epi principal surface.

The purpose of the present invention is to provide a colorectal cancer drug that uses microRNA exhibiting outstanding effectiveness in colorectal cancer patients, particularly colorectal cancer patients having a mutated KRAS gene. miR4689 and/or miR4685-3p can suppress the growth of colorectal cancer cells, particularly colorectal cancer cells having a mutated KRAS gene, and thus exhibit an effective antitumor effect.

Colorectal cancer drug, and method for predicting prognosis of colorectal cancer patient

Provided is a novel useful microRNA having improved anti-tumor activity, obtained by introducing a variation in a microRNA which is present in-vivo and which exhibits an anti-tumor effect. This microRNA containing a base sequence (SEQ ID NO: 1) obtained by varying a predetermined region of the base sequence of miR-29b is able to exhibit a particularly outstanding anti-tumor effect.

RNA sequence having anti-tumour activity

An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.

Enhancer of anti-tumor effect of anti-cancer agent

Growing community of inventors

Osaka, Japan

Hirofumi Yamamoto