Daiichi Pharmaceutical Co., Ltd.

Kabushiki Kaisha Yakult Honsha

Other

Daiichi Seiyaku Co., Ltd.

Hirofumi Terasawa

Akio Ejima

Satoru Ohsuki

Tsunehiko Soga

Kouichi Uoto

Takashi Ishiyama

Hiroaki Tagawa

Shigeru Noguchi

Kazuaki Kanai

Shinji Kamihara

Hiroaki Kitaoka

Masamichi Sugimori

Kiyoshi Nakayama

Pentacyclic Compound

Condensed-hexacyclic compounds and a process therefor

Pentacyclic compound

Hexa-cyclic compound

The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1).

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.

Method for treating leukemia with a hexa-cyclic compound

Deacetoxytaxol derivatives

Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7]

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formura: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.

Hexa-cyclic camptothecin derivatives

A pyranoindolizine derivative represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or hydroxyl group and Q denotes &gt;C.dbd.O or ##STR2## with a proviso that Q is other than &gt;C.dbd.O when R is a hydrogen atom. Its preparation process is also described.

Certain pyrano (3,4-f)-indolizine derivatives

Growing community of inventors

Tokyo, Japan

Hirofumi Terasawa