Eisai R&d Management Co., Ltd.

Eisai Company, Limited

Hirofumi Kuroda

Taiju Nakamura

Yusuke Ayata

Taichi Abe

Atsushi Akao

Yusuke Miyashita

Katsuya Tagami

Jun Niijima

Ikuo Kushida

Akio Kayano

So Yasui

Nobuo Niikawa

Yoko Ito

The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34&#x3bb;,39&#x3bb;-diphosphaoctacyclo[28.6.4.10.10000]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.

Salts of compounds and crystals thereof

Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less. 

High-purity quinoline derivative and method for manufacturing same

Processes for preparing sulfoxides useful as drugs such as acid secretion inhibitors or antiulcer drugs or intermediates for the preparation of drugs in high yields, at high purities, and with safety. Specifically, a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with a peroxoborate salt in the presence of an acid anhydride or a metal catalyst; and a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with an N-halosuccinimide, 1,3-dihalo-5,5-dimethyl-hydantoin or dichloroisocyanuric acid salt in the presence of a base. In said formulae R,is hydrogen, methoxy or difluoromethoxy; R,is methyl or methoxy; R,is 3-methoxypropoxy, methoxy or 2,2,2-trifluoroethoxy; and R,is hydrogen or methyl

Process for the preparation of pyridine derivatives

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Kamisu, Japan

Hirofumi Kuroda