Km Biologics Co., Ltd.

Kumamoto University

Hirotsu Bio Science Inc.

Alnylam Pharmaceuticals, Inc.

National University Corporation Kumamoto University

Hirofumi Jono

Dinah Wen-Yee Sah

Toshihiro Nakashima

Kenji Soejima

Masaharu Torikai

Hirofumi Higuchi

Takaaki Hirotsu

Rene Alvarez

Yukio Ando

Yu Su

Akihiko Hosoi

Tomoyo Takeo

Masayo Ueno

Mineyuki Mizuguchi

The present invention provides a method for highly sensitively and highly specifically detecting a kidney cancer. According to the present invention, there is provided, for example, a method for detecting a kidney cancer in a subject, comprising diluting a urine sample obtained from the subject at a predetermined ratio, and determining whether or not nematodes exhibit attraction behavior toward the diluted urine sample, wherein the predetermined ratio is 200 or more.

Method for detecting kidney cancer

A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.

Anti-transthyretin human antibody

A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.

Anti-transthyretin humanized antibody

Growing community of inventors

Kumamoto, Japan

Hirofumi Jono