Shiseido Company, Limited

Other

Hirofumi Aoki

Ohji Ifuku

Jiro Kishimoto

Kenichi Umishio

Antonis S Zervos

Shigeyoshi Fujiwara

Tomomi Okazaki

Osamu Moro

Ki Sai

Takeshi Hariya

Naomi Ota

The purpose of the present invention is to develop a method or system for measuring the skin condition easily and accurately. The method for determining the skin condition based on the thermal sensitivity in the skin was perfected by discovering that the skin condition, especially the skin barrier function, can be determined based on the thermal sensitivity in the skin.

Method for determining skin condition based on thermal sensitivity in skin

The present invention provides a skin test method for predicting the formation of spots in the skin. This method is characterized by judging skin to be susceptible to spot formation in the case expression of genes consisting of MLSTD1, MOGAT1, FADS2, FADS1, HSD3B1, ELOVL3, BG1, PECR, FABP7, FA2H, HAO2, ALOX15B, PDE6A, LZTS1, SEC14L4, BAMBI, CIDEA, TERE1, GAL, THRSP, INSIG1 or CUTL2 in the epidermis is accelerated, or the expression of genes consisting of RBBP6, MSMB, WIF1, ANKRD12, FLG, SYNE2, SCEL, NKTR or AMBP in the epidermis is decreased as compared with normal expression in the epidermis.

Method of predicting spot formation on the skin using spot site-accelerating genes as an indicator thereof and method of screening inhibitors of spot formation on the skin

An endermic liniment which characteristically contains an extract from a plant of the Solanaceae family (Solanaceae), genus Withania (Withania). A whitening endermic liniment with a superior whitening effect can be provided.

External preparations for skin whitening

The specification relates to a gene which is involved in the control of melanin production in human melanocytes. Human homologs of rat rKr2 gene and their fragments, and a method for evaluating melanin production ability in human melanocytes using such fragments are also disclosed. These subject matters are useful mainly in the cosmetic and dermatological fields.

Gene for inhibiting melanin biosynthesis

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Yokohama, Japan

Hirofumi Aoki