Toyo Suisan Kaisha, Ltd.

Other

Ajinomoto Co., Ltd.

Hiroeki Sahara

Noriyuki Sato

Kazuyoshi Masaki

Kengo Sakaguchi

Fumio Sugawara

Takayuki Yamazaki

Keisuke Ohta

Tatsuya Fujita

Kotaro Nakayama

Manabu Suzuki

Junji Hamuro

Toshihiko Torigoe

Kokichi Kikuchi

Yoko Mori

Noriko Asano

Mika Takenouchi

Masahiko Miura

Hiroshi Murata

Nobuaki Takahashi

Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein Ris an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and pharmaceutically acceptable salts thereof are effective for treating tumors.

Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same

A method for treating an adenocarcinoma excluding colon cancer, lung cancer and gastric cancer, comprising administering to a subject in need thereof and suffering from adenocarcinoma cancer, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol compound represented by formula (1): wherein Rrepresents an acyl residue of an unsaturated higher fatty acid, and Rrepresents a hydrogen atom, and/or at least one pharmaceutically acceptable salt thereof.

Method for treating cancer

A method for treating a cancer. The cancer excluding an adenocarcinoma and being epithelioma, glioma, sarcoma, melanoma, lymphoma or leukemia; or the cancer is an adenocarcinoma cancer excluding colon cancer, lung cancer and gastric cancer. The method comprises administering to a subject in need thereof and suffering from cancer, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol compound represented by formula (1): wherein Rrepresents an acyl residue of an unsaturated fatty acid and Rrepresents a hydrogen atom and/or at least one pharmaceutically acceptable salt thereof.

A tumor antigen gene is identified by screening a cDNA library derived from a gastric cancer cell line that can induce gastric cancer antigen specific cytotoxic T cell (CTL) by means of hybridization and PCR utilizing an amino acid sequence of peptide fragment of a known gastric cancer antigen protein, introducing a selected cDNA clone into a cell of gastric cancer cell line that cannot induce gastric cancer antigen specific CTL so that the clone should be expressed in the cell, and selecting a transgenic cell that has acquired the ability to induce CTL. According to the present invention, there are provided a protein capable of inducing immune response against human gastric cancer, DNA encoding the protein, as well as vaccine for treatment and prevention of human gastric cancer, and agent for treatment and prevention of human gastric cancer.

Human gastric cancer antigen gene and gastric cancer antigen protein

An immunosuppressive agent comprising, as an effective ingredient, at least one compound selected from the group consisting of compounds represented by general formula (1) below and pharmaceutically acceptable salts thereof:wherein Rrepresents an acyl residue of a higher fatty acid, and Rrepresents a hydrogen atom or acyl residue of a higher fatty acid.

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Sapporo, Japan

Hiroeki Sahara