Toray Industries, Inc.

Hiroe Hirokawa

Mie Kaino

Hiroyuki Meguro

Kozue Takagaki

Naoyoshi Yamamoto

A method of treating or preventing multiple sclerosis includes administering a therapeutically effective amount of a cyclohexane derivative represented by Formula (I): wherein A is a substituent represented by Formula (IIa) or (IIb): Rand Rare each independently a hydrogen atom, chlorine atom, C-Chaloalkyl, C-Calkyl, C-Calkoxy, or cyano; Ris a hydrogen atom or chlorine atom; Ris a fluorine atom, hydroxymethyl, or hydroxyl; Rand Rare each independently a hydrogen atom, fluorine atom, C-Chaloalkyl, carboxyl, methoxycarbonyl, ethoxycarbonyl, C-Calkoxy, hydroxyl, or C-Calkylcarbonyloxy, or optionally together form oxo; Rand Rare each independently a hydrogen atom or fluorine atom; Y is an oxygen atom or sulfur atom; and Z is a nitrogen atom or methine or a pharmaceutically acceptable salt thereof to a mammal.

Methods of treating or preventing multiple sclerosis

A therapeutic or prophylactic agent for leukemia is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for leukemia according to the present invention shows the excellent absorbability and in vivo stability when orally administered, and exhibits prominent therapeutic or prophylactic effects. 

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Kamakura, Japan

Hiroe Hirokawa