Corvia Medical, Inc.

Mitralign, Inc.

Dc Devices, Inc.

Edwards Lifesciences Corporation

Hiroatsu Sugimoto

Edward I McNamara

Stephen Forcucci

David Stephen Celermajer

Matthew J Finch

Aaron M Call

Joseph P Lane

Paul A Spence

Michael W Sutherland

Donald S Baim

Jason Robinson

Karl R Leinsing

Christopher J Magnin

David Celermajer

Edward Mcnamara

Mark A Maguire

Steven D Cahalane

Richard J Morrill

Christopher Lee

Kate E Cutuli

Harith Rajagopalan

John Mitzel

Michael J Sutherland

Edward I Mcnamara

Christopher Magnin

The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal. The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

Apparatus and methods to create and maintain an intra-atrial pressure relief opening

Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.

Tissue anchors, systems and methods, and devices

Several unique intra-cardiac pressure devices, placement catheters, methods of placement and methods of treating heart failure are presented. The intra-cardiac pressure devices presented allow sufficient flow from the left atrium to the right atrium to enable the relief of elevated left atrial pressure and resulting patient symptoms. The intra-cardiac pressure devices are made of a non-braided material.

Intra-atrial implants made of non-braided material

A tissue anchor includes an anchor member formed from a generally flexible material. An activation member, which may be a tensioning member, causes proximal and distal end portions of the anchor member to move toward each other into a shortened configuration suitable for anchoring against the tissue. The tissue anchor can optionally be deployed and activated using a catheter device.

Tissue anchor and anchoring system

The present teachings generally relate a delivery system having an implant retention mechanism. Specifically, the delivery system includes a delivery sheath, a delivery catheter, and a flexible or a rigid implant retention mechanism. The flexible implant retention mechanism includes an implant retention string having a fixed end and a free end where the free end extends from the fixed end, crosses a retention outlet of an implant, and extends proximally through a lumen of the delivery sheath. The rigid implant retention mechanism includes an implant retention wire having a fixed end and a free end where the free end extends from the fixed end, crosses a retention outlet of an implant, and extends proximally through a lumen of the delivery sheath.

Implant retention attachment and method of use

The present disclosure relates to improved capabilities for stabilizing and regulating atrial pressure with a shunt in the atrial septum or a stent in the coronary sinus. The disclosure also includes sensing, monitoring, drug therapy and control capabilities to provide improved treatment of patients with heart disease and other cardiac related conditions.

Atrial pressure regulation with control, sensing, monitoring and therapy delivery

The invention is a septal implant that can accommodate variable thicknesses of the patient's atrial septum as well the variable thicknesses of septums across a population. The invention is able to accomplish this result by having flexible annular flanges that define a gap into which the septum fits. Due to the flexible nature of the annular flanges, the gap is adjustable.

Intra-atrial implants having variable thicknesses to accommodate variable thickness in septum

Several unique intra-cardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intra-cardiac pressure vents presented remain partially open under normal intra-cardiac pressures to allow sufficient flow from the left atrium to the right atrium to enable the relief of elevated left atrial pressure and resulting patient symptoms, and also limit the amount of flow from the right atrium to the left atrium by closing when the pressure in the right atrium exceeds the pressure in the left atrium by a predetermined amount.

Devices, systems, and methods to treat heart failure having an improved flow-control mechanism

Several unique intracardiac pressure vents, placement catheters, methods of placement and methods of treating heart failure are presented. The intracardiac pressure vents presented allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms but also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombus or other embolic material from entering the arterial circulation.

Intra-atrial implants to directionally shunt blood

Devices and methods to enhance the implantation, retrievability, or repositionability are provided. Embodiments of devices include pivotable sections providing the ability to maintain the device's engagement with a delivery system during implantation where the deliver system approaches an opening of the septum at an angle. Embodiments of devices also include configurations that allow for improved retrieval into a delivery system in the event that a malfunction or a problem with the patients physiology is detected.

Devices and methods for retrievable intra-atrial implants

Devices and methods for treating heart disease by normalizing elevated blood pressure in the left and right atria of a heart of a mammal are disclosed. Devices may include an adjustable hydraulic diameter shunt portion which can be manually adjusted in vivo. Methods are provided for adjusting the flow rate of the devices in vivo.

Methods and devices for intra-atrial shunts having adjustable sizes

A system is provided for delivering respective anchors into spaced apart locations along an annulus of a mitral valve. The system includes a first catheter member having a first lumen formed therein for receiving a first guide wire and also includes a second catheter member that is configured to move between an expanded position and a collapsed position relative to the first catheter member. The second catheter member has a lumen formed therein for receiving a second guide wire when the second catheter member is in the expanded position. The second catheter member is fixedly connected to the first catheter member by a first connector (that defines first and second living hinges) which is configured to deploy under a select condition to automatically cause the second catheter member to move to the expanded position.

Growing community of inventors

Cambridge, MA, United States of America

Hiroatsu Sugimoto