Chugai Seiyaku Kabushiki Kaisha

Teijin Limited

Suntory Limited

Teijin Pharma Limited

Hiroaki Takayama

Hiroshi Saito

Sachiko Yamada

Katsuhiro Konno

Toshie Fujishima

Kazuya Takenouchi

Seiichi Ishizuka

Nozomi Saito

Tatsuo Suda

Kazuhisa Okada

Masayuki Ohmori

Daishiro Miura

Yasuhiro Itagaki

Nobufumi Kawai

Atsushi Kittaka

Keiko Nakayama

Miyuki Anzai

Miyuki Anzal

A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein Rrefers to hydrogen atom, C-Calkyl group optionally substituted with hydrogen group or C-Calkoxy group optionally substituted with hydroxyl group, Rand Rrefer to hydrogen atom, C-Calkyl group optionally substituted with hydroxyl group, C-Caryl group optionally substituted with hydroxyl group or C-Caralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which Ris a hydrogen atom or a methyl group and Rand Rare hydrogen atoms is excluded].

[object Object]

Provided are 1,25-dihydroxy-2-methylvitamin D3 derivatives expressed by the general formula (I),[wherein each of Rand Ris independently a hydrogen atom or a tri(Cto Calkyl)silyl group; herein configurations of asymmetric carbons at the 1-, 2- and 3-positions are each independently &#x3b1;-configuration or &#x3b2;-configuration] and their production methods. The compound is useful as a treating agent for osteoporosis, rickets, hyperthyroidism, etc.

Vitamin D3 derivative and its production method

Pompilid wasp-derived neuropeptides

There are disclosed 6,19-epidioxyvitamin D.sub.3 derivatives which are represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen atom or a hydroxyl group; when R.sub.1 is a hydrogen atom, R.sub.2 represents a hydroxyl group and R.sub.3 is a hydrogen atom or a hydroxyl group; when both R.sub.1 and R.sub.2 represent a hydroxyl group, R.sub.3 is a hydrogen atom or a hydroxyl group; and when R.sub.1 is a hydroxyl group and R.sub.2 is a hydrogen atom, R.sub.3 represents a hydroxyl group. The compounds are highly capable of inducing differentiation of human myeloid leukemia cells with minimum effects on calcium metabolism and are useful as an agent to treat leukemia.

Novel vitamin D.sub.3 derivatives and process for producing the same

A 24,25-dihydroxycholestane derivatives of the formula ##STR1## wherein A is a steroid residue and R is an aryl group and a process for preparation of the same are disclosed. The derivatives are an intermediate for synthesis of 24,25-dihydroxycholecalciferol having useful physicological activity like that of vitamin D.sub.3. 24,25-Dihydroxycholecalciferol can be produced in an industrially advantageous method via the intermediate which is easily prepared from commercially available starting compounds.

24,25-Dihydroxycholestans and process for preparing the same

Growing community of inventors

Tokyo, Japan

Hiroaki Takayama