Chugai Seiyaku Kabushiki Kaisha

Osaka University

Hiroaki Susumu

Tomoyuki Igawa

Yutaka Matsuda

Yuji Hori

Shun Shimizu

Hiroki Kawauchi

Kanako Tatsumi

Hiroki Hayashi

Masaki Kamimura

Yasunori Komori

Hitoshi Katada

Shimon Sakaguchi

The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Pc region and methods of producing and using the polypeptides.

Anti-CTLA-4 antibody and use thereof

The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.

Growing community of inventors

Kanagawa, Japan

Hiroaki Susumu