Nisshin Flour Milling Co., Ltd.

Hiroaki Satoh

Haruhiko Kikuchi

Koichiro Hagihara

Setsuko Mino

Masashi Suzuki

Takeo Arai

Toru Hayakawa

Ruta Fukutomi

Makoto Yanai

Toshiji Sugai

Masahiro Ueno

Yumiko Noguchi

Norio Oshida

Einosuke Sakurai

Kohei Inomata

Koichi Itoh

Shinji Yokoyama

Hiroshi Sakai

Tamiko Hamada

Toshio Suguro

Tomomi Tonoike

Sugure Taniguchi

Yoji Mimaki

Nobuhiro Yahata

Yukiko Muraki

Haruko Eguchi

Ryuta Fukutomi

Kazumi Nishimura

Hiroyasu Koyama

Yoshikuni Suzuki

Kazuhiko Yamada

Koichi Watanabe

Kiochiro Hagihara

An indazole compound having a piperazinyl moiety in the structure thereof, which is a 5-HT.sub.4 receptor agonist which is useful in the treatment of digestive tract disorders.

Indazole compound containing a monocyclic amine structure

Pyridinecarboxamide derivatives

Indazole derivatives having monocyclic amine

Diaminomethylidene derivatives

Pyrimidine derivatives

Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.

5-HT.sub.4 receptor agonists

Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;

Diazabicyclo derivatives

Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;

Azabicyclo derivatives

Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Piperidine derivatives

Azabicyclo derivatives and their use as antiemetics

Disclosed are compounds of formula I ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, benzyl or an indolyl carbonyl group, R.sub.2 is a saturated or unsaturated 5- or 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C.sub.1 -C.sub.6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain --(CH.sub.2).sub.n -- are optionally substituted by a C.sub.1 -C.sub.6 alkyl, phenyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Indole derivatives

Compounds are described of the formula ##STR1## wherein R.sub.1 is a nitro or trifluoromethyl group; R.sub.2 is a C.sub.1 -C.sub.6 alkyl group; R.sub.3 is a pyridyl or pyridyl N-oxide group which may be substituted with halogen, hydroxyl, haloalkyl, C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkyl and further may be fused with a benzene or naphthalene ring, said ring being optionally substituted with C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halogen or haloalkyl, and a pharmaceutically acceptable acid addition salt thereof. The compounds of the formula (I) are of vasodilating and blood pressure lowering activities and thus may be useful for the treatment of cardiac diseases, cerebrovascular diseases and hypertension.

1,4-Dihydropyridine derivatives and pharmaceutical compositions

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Ohimachi, Japan

Hiroaki Satoh