Panasonic Corporation

Matsushita Electric Industrial Co., Ltd.

Panasonic Intellectual Property Management Co., Ltd.

The Ritsumeikan Trust

Matsushita Technical Information Services Co., Ltd.

Hiroaki Oka

Tetsuo Yukimasa

Hidenobu Yaku

Nobuhiko Ozaki

Hirokazu Sugihara

Masaya Nakatani

Akio Oki

Ryuta Ogawa

Atsushi Nishino

Toshikazu Tomioka

Katsumi Tomita

Fumiaki Emoto

Kenji Hoshino

Masato Suzuki

Yukari Hataoka

Shigeharu Ueda

Hidehiro Sasaki

Makoto Taketani

Yosuke Hanai

Yasuo Mori

Shigeki Kiyonaka

Maki Yotsuhashi

Nobuhiro Hayashi

Norihito Tsukahara

Soichiro Hiraoka

Hiroshi Ushio

Satoshi Konishi

Yasushi Kobayashi

Akiyoshi Oshima

Atsuo Nakao

Takahiro Nogami

Takeki Yamamoto

Takeshi Yanagida

Katsuyuki Tsuji

Daniel Yazbeck

Ken Shimono

Maki Katagiri

Yukifumi Yoshimoto

A chemical substance concentrator includes a channel allowing a sample containing a chemical substance to flow in a flowing direction in the channel, and a cell wall partitioning the channel into adsorption cells. Each of adsorption cells includes first and second electrodes disposed on the cell wall apart from each other and an adsorption device that adsorbs the chemical substance. The adsorption device contains metal oxide. The absorption device is disposed at a position contacting the first electrode and the second electrode such that the first and second electrodes are electrically connected via the adsorption device.

Chemical substance concentrator and chemical substance detector

An object is to provide an electrophoretic support body and an electrophoretic device which allow a potential of hydrogen (pH) to be easily and reproducibly adjusted. The electrophoretic support body in the present disclosure is an electrophoretic support body including a plurality of fibers, the plurality of fibers form a fibrous body having a void in the fibrous body, and the plurality of fibers include a metal oxide having a predetermined isoelectric point. The electrophoretic device in the present disclosure includes a container, a pair of first electrodes provided in the container, and a first electrophoretic support body disposed between the pair of first electrodes, the first electrophoretic support body includes a fibrous body that is formed of a plurality of fibers and has a void in the fibrous body, and the plurality of fibers include a metal oxide having a predetermined isoelectric point.

Electrophoretic support body and electrophoretic device

A filter device of the present disclosure includes at least a sheet-shaped fiber structure having a plurality of fibers made of amorphous silicon dioxide, wherein the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure. A filter device of the present disclosure corresponds to an analysis device including: a substrate; a flow path formed on the substrate; and a sheet-shaped fiber structure provided on the inner wall of the flow path, wherein the sheet-shaped fiber structure includes a plurality of fibers made of amorphous silicon dioxide, and the plurality of fibers are tangled and thus connected together to form voids in the sheet-shaped fiber structure.

Filter device and analysis device using same

A method for producing cAMP using a chimeric olfactory receptor. The method includes a step of preparing a reaction system comprising a first layer, a lipid bilayer membrane, and a second layer, and a step of supplying a chemical substance which stimulates the chimeric olfactory receptor to the first layer so as to produce the cAMP from ATP. The lipid bilayer membrane includes the chimeric olfactory receptor and adenylate cyclase. The chimeric olfactory receptor penetrates the lipid bilayer membrane. The second layer contains ATP and a G protein. The G protein is placed in the vicinity of one end of the chimeric olfactory receptor. The chimeric olfactory receptor is derived from a mouse olfactory receptor and the N-terminal of the chimeric olfactory receptor is modified with an amino acid sequence.

Method for producing cAMP using chimeric olfactory receptor

An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode. The pharmacologic measurement instrument detects a change in electric signal caused by a pharmacologic action or electrophysiologic action of a biologic specimen, and includes an electrically conductive box having an opening section at the top surface thereof and a well vessel disposed in the opening section thereof, wherein the well vessel includes a base having recesses in which the biologic specimens are put; measurement electrodes formed on the bottom surfaces of the respective recesses; and reference electrodes electrically insulated from the respective measurement electrodes, and the reference electrodes together with the electrically conductive box electrostatically shields the well vessel.

Instrument and system for pharmacologic measurement and well vessel used therein

An extracellular potential measuring device includes a plate portion having a first surface and a second surface opposite to the first surface, and an electrode provided on the second surface of the plate portion. In the plate portion, a pocket having an opening which opens to the first surface is formed, and a through-hole communicating to the second surface from the pocket. The through-hole communicates from a position which is closer to the opening than a deepest point of the first pocket. The electrode is provided around of the opening of the through-hole. In this device, even if a cell to be examined does not reach the deepest point of the pocket, a cell membrane of the cell can tightly attaches onto the through-hole securely without a clearance. Hence, culture solution inside the through-hole is isolated from culture solution over an upper surface of the plate portion, thereby allowing electrochemical changes caused by activities of the cell to be detected efficiently with a detector electrode.

Extracellular potential measuring device and its manufacturing method

A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.

Extracellular potential sensing element, device for measuring extracellular potential, apparatus for measuring extracellular potential and method of measuring extracellular potential by using the same

A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily.

Device for measuring extracellular potential and method of manufacturing device

A diaphragm is formed by etching a substrate. This substrate has a first surface provided with a depression by isotropic dry etching, and a second surface opposite the first surface. Furthermore, a through-hole is formed from the depression to the second surface by anisotropic dry etching. The depression and the through-hole are formed by using one resist mask. The depression has a hemispherical shape or a semi-elliptical spherical shape.

Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm

An object of the present invention is to detect a specific chemical substance with high sensitivity and high precision. By using a specific lipid bilayer membrane, a chemical substance is detected with high sensitivity and high precision. Here, the specific lipid bilayer membrane comprises a chemical substance receptor, a chimeric G protein, and a potassium ion channel. The chimeric G protein comprises a chimeric Gsubunit and a Gsubunit complex. The chimeric Gsubunit is selected from the group consisting of G(SEQ ID NO: 04), G(SEQ ID NO: 05), G(SEQ ID NO: 07), G(SEQ ID NO: 08), G(SEQ ID NO: 12), and G(SEQ ID NO: 15).

Method for transporting potassium ions from front side to back side of lipid bilayer membrane

Provided are skin incision instrument to efficiently incise minimal portions and a method for incising skin with the skin incision instrument. The skin incision instrument according to the present invention comprises a holder, a needle, a needle drive unit, two or more skin expander sets, and a reader, wherein the skin expander sets comprise a first skin expander and a second skin expander; the first skin expander and the second skin expander are capable of expanding skin at both sides of the linear incision portion away from the linear incision portion and expanding the linear incision portion in a direction to expand the linear incision portion; and, minimal portions are efficiently incised by selecting a single skin expander set from two or more of the skin expander set based on the direction of the linear incision portion, such that an angle is adjusted to 45 degrees or more and 90 degrees or less wherein the angle is formed by the direction of the linear incision portion read by the reader and the direction to expand the skin by the single skin expander set.

Skin incision instrument and method for incising skin with the same

An object of the present invention is to provide a method for stably forming an artificial lipid membrane while suppressing the leakage and evaporation of an electrolytic solution. The present invention is an artificial lipid membrane forming method for forming an artificial lipid membrane using an artificial lipid membrane forming apparatus. The artificial lipid membrane forming apparatus comprises a first chamber, a second chamber, a dividing wall, and an artificial lipid membrane forming portion. Each of the first chamber and the second chamber has a capacity of not smaller than 10 pl and not larger than 200 &#x3bc;l. The artificial lipid membrane forming method of the present invention comprises the steps of: preparing the artificial lipid membrane forming apparatus; adding to the first chamber a first electrolytic solution having a viscosity of not lower than 1.3 mPa&#xb7;s and not higher than 200 mPa&#xb7;s; adding a lipid solution to the artificial lipid membrane forming portion; adding to the second chamber a second electrolytic solution having a viscosity of not lower than 1.3 mPa&#xb7;s and not higher than 200 mPa&#xb7;s; and forming the artificial lipid membrane.

Method for forming artificial lipid membrane

Apparatus for measuring extracellular potential

The present disclosure relates to a method for assessing if a patient is affected with a lung cancer. The method includes analyzing the presence and amount of cyclohexanone contained in the urine excreted from the patient and determining if the presence and amount of cyclohexanone is indicative of lung cancer.

Method for determining whether or not a mammal is affected with a lung cancer

The present disclosure relates to a method for assessing if a patient is affected with a lung cancer. The method includes analyzing the presence and amount of &#x3b2;-citronellol contained in the urine excreted from the patient and determining if the presence and amount of &#x3b2;-citronellol is indicative of lung cancer.

Growing community of inventors

Osaka, Japan

Hiroaki Oka