Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Hiroaki Ohtake

Masayoshi Murata

Toshiyuki Chiba

Fumiyuki Shirai

Satoru Kuroda

Hideo Tsutsumi

Kohji Hattori

Hiroshi Kayakiri

Kiyoshi Taniguchi

Hidenori Ohki

Naoaki Fujii

Minoru Sakurai

Hitoshi Hamashima

Toshio Yamanaka

Hiroaki Mizuno

Takeshi Nakai

Yasuyo Tomishima

Takuya Makino

Shigeki Kunikawa

Junya Ishida

Ayako Toda

Kenichi Washizuka

Masashi Imanishi

Yu Harayama

Yutaka Nakajima

The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

Cyclic peptide compounds

The present invention relates to a compound formula (I) wherein X is bond or &mdash;O&mdash;CH &mdash;, (II) or (III) R is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s), and B is hydrogen; halogen; lower alkyl; lower alkoxycarbonyl; cyclo(lower)alkyl; or a heterocyclic group, naphthyl, 1,2,3,4-tetrahydronaphthyl, benzyl or phenyl, each of which may be substituted with one or two substituent(s), or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiures or urinary incontinence.

Aminoalcohol derivatives

1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxyic acids having antimicrobial activity have been prepared.

The invention relates to the preparation of 3,4-disubstituted-2-azetidinone compounds of the formula: ##STR1## in which R.sup.1 is hydrogen or amido-protective group, R.sup.2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R.sup.3 is lower alkyl, and R.sup.4 is 1-(lower)alkyl-1-hydroxy(C.sub.2 -C.sub.6)alkyl, 1-(lower)alkyl-1-(protected hydroxy)-(C.sub.2 -C.sub.6)alkyl or 2-thioxothiazolidin-3-yl, useful as an intermediate for the production of antimicrobial agents by reacting a compound a compound of the formula: ##STR2## in which R.sup.5 is acyl, or salts thereof, with a compound of the formula:

3,4-disubstituted-2-azetidinone derivatives and processes for

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Suita, Japan

Hiroaki Ohtake