Bristol-myers Company

Bristol-myers Squibb Compnay

Basilea Pharmaceutica Ag

Hiroaki Ohkuma

Masataka Konishi

Hiroshi Kawaguchi

Fumihide Sakai

Yutaka Hoshino

Hideo Koshiyama

Toshikazu Oki

Koji Tomita

Hideo Kamei

Kyoichiro Saitoh

Kiyoshi Matsumoto

Takeo Miyaki

Masami Hatori

Nobuo Shimma

Takeshi Murata

Yosuke Sawada

Osamu Tenmyo

Masahiro Sakaitani

Eisaku Mizuguchi

Masami Kohchi

Kazunao Masubuchi

Takehiro Okada

Seikichi Kobaru

Masahiro Aoki

Takahide Watanabe

Mieko Yanagisawa

Derek Hook

Yuri Yasuda

Cyclic compounds

Disclosed is the novel compound BU-4664L and derivatives thereof. The compound is produced by fermentation of Micromonospora sp. M990-6. The compound possesses anti-inflammatory and/or anti-tumor cell activities. BU-4664L has the following structure: ##STR1##

Compound produced by a strain of micromonospora

Novel compounds derived from cultures of Streptomyces sp. AA2807 are useful as 5-lipoxygenase inhibitors.

Antibiotic 5-lipoxygenase inhibitors

The novel antitumor antibiotic designated herein as BU-3420T is produced by fermentation of Micromonospora chersina strain M956-1 (ATCC 53710). BU-3420T and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors such as P388 leukemia in mice.

BU-3420T antitumor antibiotic

The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.

Antitumor antibiotic BU-3285T

Antitumor antibiotic BU-3285T compounds

BU-3420T antifungal antibiotic

BU-3420T Antitumor antibiotic

A novel antibiotic complex designated herein as BBM-1675 complex is produced by fermentation of certain novel strains of Actinomadura verrucosospora. The complex may be separated into two major components, BBM-1675 A.sub.1 and A.sub.2, and four minor components, BBM-1675 A.sub.3, A.sub.4, B.sub.1 and B.sub.2, and such components exhibit both antimicrobial activity and antitumor activity.

BBM-1675, a new antitumor antibiotic complex

There is disclosed an antibiotic complex designated as BU-2231 V which is produced by fermentation of a BU-2231-producing strain of Streptoalloteichus hindustanus, ATCC 31158. Complex BU-2231 V is recovered and purified from the fermentation broth by use of ion exchange chromatography techniques. Structural analysis shows that the complex is a mixture of components which are .gamma.-homopolymers of D-.alpha.,.gamma.-diaminobutyric acid having an average molecular weight of from about 5,100 to about 5,200. BU-2231 V has been found to be effective to inhibit growth of various Gram-positive and Gram-negative bacteria and of the herpes simplex virus.

Antiviral antibiotic complex

The actinomycete 'Actinomadura sp.' designated in our culture collection as Strain No. G455-101 has been deposited with the American Type Culture Collection under the Accession Number ATCC No. 31491. The taxonomic description of this microorganism is presented in detail in the specification as are instructions for fermenting aqueous nutrient media with it to produce the BBM 928 antibiotic complex. The BBM 928 complex has utility as an antibacterial agent against gram-positive and acid fast bacteria and exhibits antitumor activity against experimental animal tumors.

Microorganism for BBM 928 production

Antitumor antibiotic complex

A novel antibiotic complex designated herein as BBM-1675 complex is produced by fermentation of certain novel strains of Actinomadura verrucosospora. The complex may be separated into two major components, BBM-1675 A.sub.1 and A.sub.2, and four minor components, BBM-1675 A.sub.3, A.sub.4, B.sub.1 and B.sub.2, and such components exhibit antimicrobial activity and also antitumor activity in certain mouse tumor systems.

BBM-1675, a new antibiotic complex

BBM-928 is a mixture of antitumor antibacterial substances produced by fermentation of Actinomadura sp., ATCC No. 31491, under controlled conditions. The components may be separated by silica gel thin layer chromatography and by other means.

Fermentation process for BBM-928

Growing community of inventors

Tokyo, Japan

Hiroaki Ohkuma