Sumitomo Rubber Industries Limited

Taisei Kako Co., Ltd.

Hiroaki Nakano

Taiji Horita

Hiroyuki Kaneko

Yoshikazu Masuyama

Eiji Yao

Yuki Sakashita

Seiji Hara

Hideyuki Okuyama

Katsushi Maeda

Yasuhiko Kondo

Shinya Iwano

Naoyuki Ishida

Junji Tashiro

Makoto Kuroki

Masaya Umezaki

Yuki Tanaka

A gasket includes a main body made of an elastic material, and a film laminated on the surface of the main body. The gasket has a film circumferential surface portion to be brought into contact with an inner peripheral surface of a syringe barrel, and an annular groove formed circumferentially of the film circumferential surface portion. The gasket further includes an annular member which is fixed in the annular groove and includes an annular projection projecting from the surface of the film.

Medical syringe, gasket for use in the syringe, and production method for the gasket

Laminated gasket free from liquid drug leakage. Gasket () to be used for a medical syringe includes main body () made of an elastic material and film () on a surface of main body (). Gasket () has a circumferential surface portion () that can contact an inner peripheral surface of syringe barrel () of the syringe, and has an annular groove () formed circumferentially in a surface portion of the film present in the circumferential surface portion thereof. Annular groove () has outer edge portions () provided along opposite edges () thereof as projecting from an unprocessed surface portion of the film. Annular groove () has groove formation start points and end points that are connected to each other in a groove connection region. Outer edge portions () along the opposite edges of the annular groove have a maximum-to-minimum height difference of &#x2264;5 &#x3bc;m in the groove connection region.

Medical syringe, gasket to be used for syringe, and gasket production method

A laminated gasket () to be used for a medical syringe is provided, which includes a main body () made of an elastic material, and a film () provided on a surface of the main body (). The gasket () has a circumferential surface portion () to be brought into contact with an inner peripheral surface () of a syringe barrel () of the syringe. The gasket () further includes a projection () provided on a surface portion of the film () present in the circumferential surface portion () as extending circumferentially of the gasket. The projection () has a height of not less than 15 &#x3bc;m and not greater than 55 &#x3bc;m and a width of not less than 30 &#x3bc;m and not greater than 75 &#x3bc;m. With this arrangement, the laminated gasket is excellent in sealability.

A gasket () is used for a medical syringe (), and includes a main body () made of an elastic material and an inert resin film () provided on a surface of the main body (). The gasket () has a cylindrical shape, and includes a plurality of annular ribs () provided on an outer circumferential surface () thereof and each having a sliding contact portion () to be kept in sliding contact with an inner peripheral surface of a syringe barrel. The plurality of annular ribs are axially arranged from a distal end to a rear end of the gasket (). The sliding contact portion () of a distal annular rib () has a width that is 1 to 25% of axial length of the cylindrical gasket.

Gasket, and medical syringe

In a conventional laminated gasket production method, when a product of a laminated gasket is demolded from a mold, the product is rubbed against the mold and, therefore, minute scratches are formed on a surface of the laminated gasket. These minute scratches are liable to prevent reliable sealing of a liquid drug. The present invention is a method for producing a gasket to be used for a medical syringe and is characterized by including the steps of: preparing a gasket molding mold; molding a gasket having a circumferential surface portion in the mold with the gasket being laminated with a lamination film; and demolding the gasket from the mold, and then forming a groove only in the lamination film circumferentially of the circumferential surface portion of the gasket.

Medical syringe, gasket used for syringe and method for producing same

A gasket () for use in a medical syringe is provided, which includes a main body () made of an elastic material, and a lamination film () provided on a surface of the main body (). The gasket () has a circumferential surface portion () to be kept in contact with an inner peripheral surface of a syringe barrel () of the syringe. The gasket () has a groove () provided in the circumferential surface portion () thereof as extending circumferentially thereof. The groove () has a depth of not less than 0.8D (&#x3bc;m), preferably not less than D (&#x3bc;m), wherein D (&#x3bc;m) is the thickness of a portion of the lamination film () present in the circumferential surface portion () of the gasket ().

Medical syringe, gasket for use in the syringe, and gasket production method

The present invention aims to provide a medical rubber stopper that is excellent in chemical resistance and airtightness while having good productivity. The present invention relates to a medical rubber stopper including: a disk-shaped head portion with a flange region; and a cylindrical leg portion protruding from the lower surface of the head portion and having a smaller diameter than the head portion, the lower surface of the flange region and the leg portion being laminated with an inert film, the lower surface of the flange region and/or the outer periphery of the leg portion being provided with an annular groove through which the base rubber is exposed.

Medical rubber stopper and method for producing medical rubber stopper

Laminated gasket free from liquid drug leakage. A gasket () for a medical syringe, with main body () made of elastic material, and film () provided on a surface of main body (). Gasket () has a circumferential surface portion () for contact with an inner peripheral surface of a syringe barrel () and an annular groove () formed circumferentially in a surface portion of the film in the circumferential surface portion thereof. Annular groove () has outer edge portions () provided along opposite edges () thereof as projecting from an unprocessed surface portion of the film. Annular groove () has a groove formation start point and a groove formation end point connected to each other in a groove connection region. Outer edge portions () provided along the opposite edges of the annular groove have a maximum-to-minimum height difference of &#x2264;5 &#x3bc;m in the groove connection region.

When a laminated gasket product is demolded from a mold in production thereof by a conventional production process, the gasket product is rubbed against the mold and, therefore, minute scratches are formed on a surface of the gasket product. The minute scratches may impair the reliable sealability of a liquid drug. A method for producing a gasket () for use in a prefilled syringe () includes the steps of: preparing a gasket forming mold; molding a gasket () in the mold, the gasket having a surface laminated with a lamination film () and including a circumferential surface portion (); demolding the gasket () from the mold, and then simultaneously forming a groove () and a projection () each extending circumferentially of the gasket in a portion of the lamination film () present in the circumferential surface portion () of the gasket.

Prefilled syringe, gasket for use in prefilled syringe, and gasket production method

A gasket for prefilled syringe according to the present invention is a gasket for prefilled syringe that includes a fluid contacting portion, a sliding portion with a circumferential surface, a film layer made of a fluororesin coated on the fluid contacting portion and sliding portion and further, and a coating layer including trimethylsiloxysilicate laminated on the film layer covering the sliding portion.

Gasket for prefilled syringe and prefilled syringe

A pre-filled syringe with excellent air-tightness and liquid-tightness and a mold for forming the gasket are provided. At least a surface of the mold for a gasket laminated with an inactive film for a pre-filled syringe forms a seal sliding surface of an annular protrusion of the gasket is mirror finished to have an arithmetic mean roughness Ra of less than 0.03 &#x3bc;m.

Mold for gasket for prefilled syringe

The present invention aims at providing a composite of a surface-modified fluororesin film and a thermoplastic resin bonded to each other, and medical equipment containing the composite. A method for producing a fluororesin/thermoplastic resin composite includes roughening a surface of a fluororesin film by ion beam irradiation from an ion source, and pressure-bonding the surface-modified fluororesin film obtained in the surface roughening step and a thermoplastic resin while maintaining the thermoplastic resin in a fluid state.

Method for producing surface-modified fluororesin film/thermoplastic resin composite

There are provided a method for manufacturing a surface-modified fluororesin film capable of long-term inventory storage, a method for manufacturing a rubber composite composed of the surface-modified fluororesin film and rubber bonded together, and a rubber product for medical use made of the rubber composite. The method for manufacturing a surface-modified fluororesin film comprises the step of performing surface roughening on a fluororesin film RF by applying an ion beam from an anode layer ion source to the surface of the fluororesin film RF. A rubber is placed over the roughened surface of the thusly produced surface-modified fluororesin film, and, through vulcanization molding process, the surface-modified fluororesin film and the tuber can be firmly bonded to each other.

Method for manufacturing surface-modified fluororesin film, method for manufacturing rubber composite, and rubber product

A thermoplastic elastomer composition which has excellent cleanability and is suitable for use as a medical rubber supply. It is characterized by comprising a rubber ingredient dynamically crosslinked with a crosslinking agent and a matrix which comprises a thermoplastic resin and in which the crosslinked rubber ingredient has been dispersed, the crosslinking agent comprising a triazine derivative.

Growing community of inventors

Kobe, Japan

Hiroaki Nakano