Mitsui Petrochemical Industries, Ltd.

Hitachi-High-Technologies Corporation

Sony Corporation

Mitsui Chemicals, Inc.

Hitachi, Ltd.

Sumitomo Bakelite Company Limited

Toyobo Co., Ltd.

Hiroaki Nakagawa

Shinichiro Nishimura

Kisaburo Deguchi

Minoru Fujita

Nobuhiko Ando

Hirohiko Nambu

Yutaka Tentaku

Masahito Ito

Noriaki Nishi

Isao Hashimoto

Fumiaki Nakano

Masahiro Kondo

Kuriko Yamada

Takashi Nakao

Tetsuya Inoue

Fujihisa Matsunaga

Yuuichi Suzuki

Hiroyuki Kurata

Kenichi Niikura

Ichiro Imai

Masanori Takaki

Minenobu Okayama

Noriake Ohishi

Masayasu Isibasi

Genzou Hirata

Kimihiro Saito

Kazumichi Imai

Hiroshi Yoshida

Toshiro Saito

Junkichi Miura

Yoko Inoue

Yasuhiko Tada

Tsutomu Saito

Ryota Nakajima

Masatoshi Narahara

Susumu Nishiguchi

Akihiro Shimase

Shizu Takeda

Naoko Senda

Tokinori Agou

Kensaku Takahashi

Atsushi Toda

Hitomi Matsuzaki

Muneyuki Matsumoto

Toru Taguchi

Toshio Kaya

Genzo Hirata

Masahiro Kondou

Tohru Taguchi

Takamasa Tsumoto

Noriyuki Hirowatari

Takayuki Nakamura

Makoto Fujimoto

Yoichi Takehana

Keiji Suzuki

A cross section of a luminous flux of returning light from a disc is split into a plurality of regions, and an operation is performed so that a weighting of a light amount of a region which has favorable symmetry in a radial direction and is formed on a circumference of an ellipse among the split regions is increased. Further, a lens shift detection signal is formed, and a lens shift detection signal is canceled from a push-pull signal.

Optical disc device

There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (Ile, Val, Ser, Leu, and Ala), thereby making a determination.

Method for determining cell state and autoanalyzer using said method

The present invention provides substance which can specifically interact with sugar chains. Further, the present invention provides a method for separating, concentrating, or purifying sugar chains or a sugar chain-containing substance in a sample, comprising the steps of: a) contacting a sugar chain-trapping carrier comprising a substance which can specifically interact with sugar chains with the sample in a fluid phase under conditions that the sugar chain-trapping carrier can react with the sugar chains or sugar chain-containing substance; b) isolating a composite of the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance from the fluid phase; and c) exposing the composite to the conditions that the interaction between the sugar chain-trapping carrier and the sugar chains or sugar chain-containing substance is at least partially eliminated.

Method of purifying/concentrating sugar chains with a sugar chain-trapping molecule and method of analyzing sugar chain structure

Method of purifying/concentrating sugar chain with sugar chain-trapping molecule and method of analyzing sugar chain structure

This invention provides a biomolecule modifying substrate comprising biomolecules selectively fixed to given regions thereon. The biomolecule modifying substrate comprises: a substrate at least comprising a first surface and a second surface; a first linker molecule comprising a hydrocarbon chain and a functional group capable of selectively binding to the first surface at one end of the hydrocarbon chain, which is bound to the first surface via such functional group; a second linker molecule comprising a reactive group capable of binding to the hydrocarbon chain of the first linker molecule, which is bound to the first linker molecule via a bond between the reactive group and the hydrocarbon chain; and a biomolecule bound thereto via the second linker molecule.

Biomolecule fixing board and method of manufacturing the same

An information recording medium includes a plurality of wobbled tracks, in which a phase mismatch range of an adjacent wobble is a portion of a range of one track.

Information recording medium and disc

An optical pickup includes: a light source outputting a light beam; an objective lens collecting the light beam on a target recording layer as a target of plural recording layers provided in an optical disc; a lens moving unit moving the objective lens in a tracking direction nearly orthogonal to track grooves helically or coaxially formed in the target recording layer; a collective lens collecting a reflected light beam formed when the light beam is reflected by the optical disc; a diffraction optical element diffracting part of the reflected first-order light beam in predetermined directions as first, second, third and fourth beams; and a photodetector receiving the first and second beams using first and second light receiving areas, and generating light reception signals, and receiving the third and fourth beams using third and fourth light receiving areas, and generates light reception signals.

Optical pickup and optical disc device

After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.

Oligosaccharide synthesizer

An optical pickup includes: a light source that emits a light beam; an object lens that condenses the light beam on a target recording layer of an optical disk; a lens moving unit; a condensing lens; a hologram element that diffracts, in diffracting a reflected light beam and separating it into reflected zeroth-order and first-order light beams, parts of the reflected first-order light beam in a first direction and sets them as first and second beams, diffracts parts of the reflected first-order light beam in a second direction and sets them as third and fourth beams; and a photodetector that receives the first and second beams and the third and fourth beams and generates light reception signals, and receives interlayer stray light of a part of the light beam reflected by the other recording layers other than the target recording layer and generates a stray light reception signal.

Optical pickup and optical disk device

The present invention provides a sugar chain synthesizer capable of continuously reacting sugar chains when a plurality of sugar chains are successively reacted. The sugar chain synthesizer of the present invention includes a plurality of vessels containing respective sugar nucleotide solutions, a plurality of vessels containing respective glycosyltransferases, and a reactor containing a primer that is a water-soluble polymer, into which the above described sugar nucleotide solution and glycosyltransferase are introduced. In the present invention, components in a reaction solution obtained in the reactor are separated through an ultrafiltration column, and a reaction product is then returned to the above described reactor, so as to continuously synthesize sugar chains. Although it is a complicated synthesis of sugar chains, it becomes possible to carry out such synthesis continuously and automatically.

Saccharide composition synthesizer

The present invention provides a sugar chain purification instrument which can continuously and efficiently purify the sugar chain. According to the present invention, the instrument includes an immobilized protease column in which a carrier which can be packed in the column and on which protease is immobilized is packed and an immobilized glycopeptidase column in which a carrier which can be packed in the column and on which glycopeptidase is immobilized is packed, these columns being connected in series, and the reaction is carried out while continuously passing a glycoprotein to be decomposed together with a suitable buffer solution through the above columns. The step of liberation of sugar chain from the glycoprotein is highly simplified and labor-saving, and liberation of the sugar chain can be moderately and simply performed.

Saccharide composition purification instrument

A sugar chain synthesizer comprising one or more reaction columns packed with immobilized glycosyltransferase and/or glycosidase; one or more separation means, arranged downstream from the reaction columns, for separating reaction products, unreaction products and byproducts contained in the solution eluted from the reaction columns; a first pump for feeding a primer of water soluble polymer and buffer solution to the reaction columns through a first selector valve; a second pump for feeding a buffer solution and sugar nucleotide solution to any one of the reaction columns through a second selector valve; one or more circulation flow paths connecting between a flow path downstream from the separation means and a flow path upstream from each of the reaction columns; and a third selector valve, arranged between the separation means and one or more circulation flow paths, for selective connection between the separation means and a desired circulation flow path. This synthesizer ensures continuous and automatic synthesis of sugar chains even if complicated.

Sugar chain synthesizer

A pellicle comprising a pellicle film, a pellicle frame supporting the pellicle film, and an adhesive resin layer provided on the surface of the pellicle frame on the side opposite to the surface supporting the pellicle film, wherein the adhesive resin layer is formed of a combination of a hard resin layer and a soft resin layer. The pellicle can be mounted on the mask and can be removed from the mask without giving damage to the mask, and does not spoil the flatness of the mask irrespective of when the mask surface is maintained in either the horizontal direction or the vertical direction.

Pellicle

A pellicle comprises a pellicle frame, a pellicle film and at least two liners. The pellicle frame has one end face and the other end face and is provided at its central portion with an opening. The other end face of the pellicle frame is provided with an adhesion layer. The pellicle film is stretched over and attached to the one end face of the pellicle frame. The at least two liners are adhered on the adhesion layer. The at least two liners can be respectively peeled off from the adhesion layer, and when the at least two liners are respectively peeled off from the adhesion layer, a portion of the adhesion layer to which each of the liners was adhered is exposed.

Pellicle and producing method of mask with pellicle

Growing community of inventors

Sapporo, Japan

Hiroaki Nakagawa