Toyo Kohan Co., Ltd.

Yamaguchi University

Hiroaki Nagano

Shoichi Hazama

Ryouichi Tsunedomi

Hirofumi Yamano

Shuichi Kamei

Mitsuyoshi Oba

Toshiya Tsuda

A therapeutic effect of irinotecan is predicted using a predetermined genetic polymorphism. A genetic polymorphism identified by rs1980576 in APCDD1L gene, or a genetic polymorphism in linkage disequilibrium with the above genetic polymorphism is analyzed, and determination is performed based on the genotype of the genetic polymorphism.

Method for predicting therapeutic effects of irinotecan, and kit for same

In the case of using a blocking nucleic acid to prevent non-specific hybridization of a target nucleic acid with a nucleic acid probe, further excellent efficiency of detecting the target nucleic acid is achieved. A buffer composition used in hybridization of a target nucleic acid with a nucleic acid probe, wherein the buffer composition for hybridization contains a blocking nucleic acid comprising a nucleotide sequence complementary to a region comprising at least a non-detection target nucleotide in a non-target nucleic acid, in a concentration of one or more times higher than the concentration of a nucleic acid in a nucleic acid mixture consisting of the target nucleic acid and the non-target nucleic acid.

Buffer composition for hybridization and hybridization method

Growing community of inventors

Ube, Japan

Hiroaki Nagano