Kyowa Hakko Kogyo Co., Ltd.

Hiroaki Motoyama

Akio Ozaki

Shinichi Hashimoto

Haruo Seto

Tomohisa Kuzuyama

Koichiro Miyake

Shunji Takahashi

Katsuhiko Ando

Keiko Ochiai

Hideo Mori

Masaru Hasegawa

Yutaka Takano

Hideharu Anazawa

Sadao Teshiba

The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity

The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

Bacillus strains which produce HMG-CoA reductase inhibitors

Disclosed is a process for producing a compound represented by general formula (II-a):

Process for the preparation of HMG-COA reductase inhibitors

Disclosed is a process for producing amino acids such as L-threohine and L-lysine, which comprises culturing, in a medium containing methanol as a major carbon source, a microorganism which belongs to the genus Methylobacillus and which has an ability to produce the amino acid(s) and resistance to at least one member selected from the group consisting of L-threonine, L-lysine and an amino acid analogue, said microorganism being obtained by mutation of a parent strain which belongs to the genus Methylobacillus and which has an enhanced sensitivity to at least one of an antibiotic and an amino acid analogue; allowing the amino acid(s) to accumulate in the culture; and recovering the amino acid(s) therefrom.

Process for producing amino acid

Growing community of inventors

Yokohama, Japan

Hiroaki Motoyama