Nippon Chemical Industrial Co., Ltd.

Tokyo University of Science Foundation

Kagawa University

Saga University

National University Corporation Kagawa Univesity

Hiroaki Kodama

Kazuhiro Nakatsui

Nobuhiko Oohara

Keisuke Ohto

Yoshirou Kaneda

Hisashi Miyamoto

Masahira Hattori

Hiroshi Ohno

Fumio Fukai

Takuya Matsunaga

Wataru Suda

Hirokuni Miyamoto

Shinji Fukuda

Kenshiro Oshima

Toshiyuki Ito

An activity enhancer for an anticancer agent includes, as an active ingredient, a D-form amino acid residue-containing FNIII14 polypeptide, the D-form amino acid residue-containing FNIII14 being a polypeptide FNIII14 represented by SEQ ID NO: 1 in which at least one of amino acid residues at positions 1 to 13 is a D-form amino acid residue. An anticancer composition includes the activity enhancer for an anticancer agent and an anticancer agent.

Activity enhancer for anticancer agent

An anticancer agent having a novel chemical structure and high anticancer activity is provided. A phosphine transition metal complex of general formula (1) and an anticancer agent containing the complex are disclosed.  Rand R, which may be the same or different, each represent a group having 1 to 10 carbon atoms selected from a straight-chain or branched alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an adamantyl group, a phenyl group, and a substituted phenyl group; Rand R, which may be the same or different, each represent a hydrogen atom, a straight-chain alkyl group having 1 to 6 carbon atoms or branched alkyl group having 1 to 6 carbon atoms; or Rand Rare taken together to form a saturated or unsaturated ring which may have a substituted group; M represents a transition metal atom selected from the group consisting of gold, copper, and silver; and Xrepresents an anion.

Phosphine transition metal complex, process for producing same, and anticancer agent

There is provided a novel transition metal phosphine complex having excellent anticancer activity. The transition metal phosphine complex is represented by general formula (1): (wherein Rs and Rs each represent an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, a pyridyl group, or a pyrimidyl group; Rs and Rs each represent an alkyl group or a cycloalkyl group, provided that each Rand each Rare not the same group and that each Rand each Rare not the same group; As each represent a linear alkylene group or a cis-vinylene group; M represents a gold atom, a silver atom, a copper atom, or a platinum atom; and B represents an anionic species).

Transition metal phosphine complex, method for producing same, and anticancer agent containing transition metal phospine complex

A phosphine transition metal complex is expressed by general formula (1): 

Phosphine transition metal complex, method for producing the same, and antitumor agent containing the same

An anti-cancer agent contains a phosphine transition metal complex having a ferrocene skeleton, the complex being represented by general formula (3) below: 

Phosphine transition metal complex having ferrocene skeleton, process for making the same, and anti-cancer agent

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Saga, Japan

Hiroaki Kodama