Terumo Kabushiki Kaisha

Hiroaki Kasukawa

Hiroshi Goto

Hiroshi Gotou

Yasuo Kurosaki

Keiko Yamashita

Yasushi Kinoshita

Shigenori Nozawa

Katsumi Morimoto

Ryoichi Nanba

Junji Kimura

Hideto Ushijima

Toshihiko Osada

Takanobu Ishizuka

Kazuo Kawahara

Hideki Uchiyama

Junichirou Watanabe

Eiko Takeda

Shinichi Kaneda

Shinichi Tokue

A drug coating layer which is a drug coating layer having a morphological form including a plurality of elongated bodies having long axes that each crystal of a water-insoluble drug independently has on a substrate surface, in which the long axes of the elongated bodies are nearly linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. The drug coating layer can provide low toxicity and a high intravascular stenosis inhibitory effect.

Drug coating layer

A treatment device includes: a balloon; a biologically active agent part applied on an outer surface of the balloon; a protective sleeve encircling the balloon and being displaceable proximally; and an interposed member having a self-expanding function arranged between the balloon and the protective sleeve. When the protective sleeve is moved proximally in order for the balloon to be exposed to the inside of a blood vessel, the presence of the interposed member prevents the biologically active agent part from being scraped and peeled off by the inner surface of the protective sleeve.

Self-expanding interposed member spacing protective sleeve from restenosis restraining agent coated balloon catheter

This invention relates to sulfonates of .beta.-cyclodextrin polymer having a sulfur content of 10% or more, which inhibit propagation of smooth muscle cells.

Sulfonated compounds of .beta.-cyclodextrin polymer and inhibitory drug

Growing community of inventors

Kanagawa, Japan

Hiroaki Kasukawa