Nihon Medi-physics Company, Limited

National Institutes for Quantum Science and Technology

National Hospital Organization

Sony Corporation

Olympus Corporation

Olympus Medical Systems Corporation

Saturn Licensing LLC

Tokyo Institute of Technology

Terumo Cardiovascular Systems Corporation

Hiroaki Ichikawa

Hiroshi Tanaka

Tsutomu Okada

Yuki Okumura

Naomi Sugimoto

Jun Ichinose

Hideyuki Kasahara

Tatsutoshi Hashimoto

Takehiro Nishiie

Daisaku Nakamura

Akihito Kano

Taku Ito

Yoshio Honda

Masato Kiriu

Akihiro Shimazu

Gota Tonoya

Yoshifumi Maya

Mitsuhide Naruse

Yoshihiro Doi

Miho Ikenaga

Yurie Fukui

Akihiro Izawa

Hiroyuki Okudaira

Hisashi Suzuki

Kotaro Nagatsu

Tomoyuki Imai

A method for producing anAc solution includes a step (I) of irradiating aRa target with particles to generate two or more actinium radioisotopes (Ac) including at leastAc, a step (II) of dissolving theRa target after the aforementioned step to obtain a solution (1), a step (III) of separatingRa and Ac contained in the solution (1) to obtain a solution (2), a step (IV) of allowing Ac contained in the solution (2) other thanAc to decay to obtain a solution (3), and a step (V) of separating Ra and Ac contained in the solution (3) to obtain a solution (4). The solution (4) is used to produce a medicine that contains, as an active ingredient, a conjugate between a chelating agent that has formed a complex withAc, and a targeting agent.

Method for producing Ac-225 solution and method for producing medicine using Ac-225 solution

Provided is a method for producing a radiohalogen-labeled compound, the method comprises: a step in which a radiohalogen-labeling precursor compound (S-L) having a leaving group (L) capable of being nucleophilically substituted by a radioactive halide ion (X) is subjected to a radiohalogenation reaction to obtain a reaction mixture RM1 which contains the radiohalogen-labeling precursor compound (S-L) and a reaction product (S&#x2014;X) resulting from the radiohalogenation reaction; a step in which the reaction mixture RM1 is mixed with a polyvalent acid or a salt thereof to obtain a reaction mixture RM2; and a step in which the reaction product (S&#x2014;X) is purified from the reaction mixture RM2 by a solid phase extraction method.

Method for producing radiohalogen-labeled compound and method for producing radiopharmaceutical

Provided are a compound represented by the following formula (1): wherein Xrepresents a hydrogen atom or a halogen atom, Xrepresents a fluorine atom or a nitrile group, and Xrepresents a radioactive halogen atom,

2-[5-(imidazol-1-ylmethyl)pyridin-3-yl]benzimtdazole derivative compound, and medicament including same

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Hiroaki Ichikawa