Sumitomo Chemical Company, Limited

Ono Pharmaceutical Co., Ltd.

Hiroaki Hibino

Tomoyasu Yoshida

Yasunobu Miyamoto

Susumu Ohtsuka

Itsuo Okumoto

Noriyuki Hida

Hideki Ushio

Atsushi Furutani

Hirokazu Murata

Etsuko Fukuda

A method for producing a biaryl compound represented by the formula (2)Ar&#x2014;Ar&#x2003;&#x2003;(2)wherein Ar represents an aromatic group which can have a substituent, comprising conducting a coupling reaction of a compound represented by the formula (1)Ar&#x2014;Cl&#x2003;&#x2003;(1)wherein Ar represents the same meaning as defined above, in the presence of copper metal and a copper salt.

Method for producing biaryl compound

The present invention provides a method for producing a compound represented by the formula (3): wherein n is an integer of 1 to 6, characterized by the steps of hydrolyzing a solution containing an ester compound represented by the formula (1): wherein R is a lower alkyl group and n is an integer of 1 to 6, and a compound represented by the formula (2): wherein R is as defined above, adjusting the pH of the resulting solution to pH 4 to 8, and then subjecting to phase separation to obtain an organic layer containing the carboxylic acid of formula (3).

Method for producing carboxylic acid compound

A process for producing a dicarboxylic acid compound represented by the formula (4): wherein Rand Rare the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2): wherein R, Rand the wavy line have the same meanings as the above, and one of Xand Xrepresents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3): in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): wherein Rhas the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

Process for producing chromone compound

There is provided an industrially advantageous process for producing a 1-chloro-4-arylbutane represented by the general formula (2):wherein R represents hydrogen, lower alkyl, or lower alkoxy, characterized by reacting 1-bromo-3-chloropropane with a compound represented by the general formula (1):wherein R is as defined above; and X represents chlorine, bromine, or iodine, in a solvent.

Process for producing 1-chloro-4-arylbutane

The present invention concerns a process for producing crystals of 3-amino-2-hydroxyacetophenone salt having a high bulk density and improved flow properties, by treating 3-amino-2-hydroxyacetophenone of formula (1) ##STR1## or hydrogen halide salt thereof with sulfuric acid, in a solvent.

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Toyonaka, Japan

Hiroaki Hibino