Japan Tobacco Inc.

Yoshitomi Pharmaceutical Industries, Ltd.

Hiroaki Hari

Itsuo Uchida

Akira Saito

Junichi Haruta

Mutsuyoshi Matsushita

Katsuyoshi Hara

Noboru Furukawa

Koretake Anami

Kunio Iwata

Akihiro Yasuda

Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

Histidyl peptide derivatives

Growing community of inventors

Tokushima, Japan

Hiroaki Hari