Nippon Kayaku Kabushiki Kaisha

Hiroaki Hamano

Akira Shiozawa

Masahiko Yabuuchi

Minoru Masuda

Mamoru Kunishima

Shuji Kurashige

Hiroshi Miyazaki

Yasuhiko Furuta

Kikuo Imazumi

Yasuo Ishii

Masako Ikeda

Chiyoko Aoyagi

Disclosed are an N-benzenesulfonyl derivative of cephamycin C represented by the following formula: ##STR1## which can easily be separated as a solid from an aqueous solution thereof, and a process for the preparation thereof. This derivative is valuable as an intermediate leading to a cephamycin type antibiotic substance.

Derivative of cephamycin C

Novel .alpha.-methyl-.beta.-aminopropiophenone derivatives having bronchodilator activity represented by the following general formula: ##STR1## where R represents alkyl having 1-6 carbon atom benzyl or phenyl; R.sub.1 and R.sub.2 individually represent alkyl having 1-6 carbon atom or they form, joining to each other together with the adjacent nitrogen atom with or without intervening an atom other than carbon atom, a saturated heterocyclic ring which may be substituted with lower alkyl; n is an integer of 0, 1 or 2 on the proviso that R represents methyl or ethyl if n is 0, as well as their non-toxic salts are presented. Method of producing the new derivatives and the bronchodilatation method using them are disclosed as well.

Derivatives of .alpha.-methyl-.beta.-aminopropiophenone and use thereof

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Higashimurayama, Japan

Hiroaki Hamano