Sumitomo Dainippon Pharma Co., Ltd.

Bridgestone Corporation

Hiroaki Fujiwara

Yoshihiro Horiuchi

Kiyoto Sawamura

Yoshiaki Isobe

Izumi Sasaki

Daisuke Urabe

Shingo Tojo

Eiji Ideue

Hitoshi Suda

Fumitaka Kobayashi

Mitsutaka Iwata

The present invention relates to a substituted purine derivative of formula (1) wherein Ris alkoxy or the like, Ris alkyl or the like, Ring Qis aryl or the like, Wis alkylene or the like, Ring Qis aromatic carbocyclyl or the like, n is 1-4, Ris hydrogen atom or the like, Xis single bond or the like, Wis alkylene or the like, and Ris hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease. 

Substituted purine derivative

The interval along the tire circumferential direction between sipes adjacent in the tire circumferential direction is 2 to 10 times the depth of the sipes. In the depth direction of the sipes, the sipes each have at least three sipe portions divided by at least two bent portions, and a bent portion angle formed between adjacent sipe portions with one of the bent portions therebetween is greater at the tread surface side than at the sipe bottom side.

Pneumatic tire

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); Rand Rmay be the same or different and each independently represents a Calkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; Xrepresents a hydroxyl group or an aminocarbonyl group; Zrepresents a single bond or the like; and Rrepresents an optionally substituted Calkyl group, an optionally substituted Caryl group or the like). 

8-azabicyclo[3.2.1]octane-8-carboxamide derivative

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is Carylene, etc.; R, Rand Reach independently is a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, etc.; Ris an optionally substituted Caryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted Caralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.) 

Cyclic amide derivative

Growing community of inventors

Tokyo, Japan

Hiroaki Fujiwara