Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Merck Sharp & Dohme De Espana Sa

Hiranthi Jayasuriya

Sheo B Singh

Russell B Lingham

Keith C Silverman

Deborah L Zink

Fernando Pelaez

Anne W Dombrowski

Daria Hazuda

Jon D Polishook

Jun Wang

Angela Basilio

Olga Genilloud

Ignacio P Gonzalez

Manuel Sanchez

Ziqiang Guan

Oscar Salazar

Ignacio Gonzalez

Fermentation of a nutrient medium with a eubacteriumsp. yields a novel antibacterial compound of structural formula (I). 

Antibiotic compound

Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.

HIV integrase inhibitors

The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer. The compounds of this invention have the following structure: ##STR1##

Inhibitors of farnesyl-protein transferase

Growing community of inventors

Edison, NJ, United States of America

Hiranthi Jayasuriya