Lupin, Inc.

Les Laboratoires Servier

Himanshu Madhav Godbole

Girij Pal Singh

Sagar Purushottam Nehate

Umesh Babanrao Rananaware

Suhas Ganpat Tambe

Narendra Dattatray Mane

Radhakrishna Bhikaji Shivdavkar

Debashish Datta

Vilas Nathu Dhake

Rajinder Singh Siyan

Chandrakant Shriram Bhangale

Narotham Maddireddy

Ujjwal Komalsing Sisodiya

Rajendra Vishwanath Firke

Harischandra Sambhaji Jadhav

Dinesh Dnyaneshwar Dixit

Vinayak Ravindra Sathe

Adinath Murlidhar Jain

Swapnil Sudhakar Deshmukh

Ujjiwal Komalsing Sisodiya

Rajendra Viswanath Firke

The present invention is directed to polymorphic forms of Pitavastatin sodium and processes for preparation of the same.

Polymorphic forms of pitavastatin sodium

The present invention relates to a process for the preparation of Levothyroxine and salts thereof. The process described in the present invention provides increase in the yields and purity comprising the use of sodium iodide and sodium hypochlorite as iodinating agent.

Process for preparation of levothyroxine and salts thereof

The present invention provides novel process for preparation of olmesartan medoxomil (I) substantially free of olmesartan acid impurity (II) comprising, reacting trityl olmesartan medoxomil (III) with acid, filtering the precipitate of trityl alcohol, subjecting the filtrate to agitated thin film drying and recovering olmesartan medoxomil (I).

Process for the preparation of olmesartan medoxomil

A process for preparation of optically pure or optically enriched enantiomers of sulphoxide compounds of formula (I), such as omeprazole and structurally related compounds, as well as their salts and hydrates. The said process comprises 

Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds

A process for the polymerization of allylamine and its subsequent crosslinking in the presence of a dispersing agent.

Process for the preparation of cross-linked polyallylamine polymer

A dicyclohexyamine salt of compound of formula I, namely perindopril, having an X-ray powder diffraction pattern with characteristic peaks (2&#x3b8;): 8.462, 10.624, 18.693, 9.424, 17.272, 14.177, 19.499, 20.765, 21.409, and 14.540.  A process for preparation of the said salt of perindopril and its use in the purification of an impure perindopril and a process for purification of perindropril comprising formation of its salt with dicyclohexylamine. The present invention also relates to preparation of Perindopril tert-butyl amine salt directly from Perindopril dicyclohexylamine salt without isolating the free base.

Process for the purification of perindopril

A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective.    

Process for preparation of perindopril and salts thereof

A process for preparation of crystalline perindopril erbumine of formula (II) which exhibits the X-ray (powder) diffraction pattern like that shown in FIG. The process comprises reacting a solution of perindopril of formula (I), in a solvent selected from N,N-dimethylformamide, dimethyl acetals of lower aliphatic aldehydes, dimethyl ketals of lower aliphatic ketones and 1,2-dialkoxyethane with tertiary butylamine and crystallization of the erbumine salt thus obtained by heating the reaction mixture to reflux, filtering hot, cooling gradually to 20&#xb0; C. to 30&#xb0; C., and further cooling to 0&#xb0; C. to 15&#xb0; C. for 30 minutes to 1 hour and finally filtering off and drying the crystals.

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Pune, India

Himanshu Madhav Godbole