Massachusetts Institute of Technology

Himanshu Hemant Dhamankar

Won Sik Kim

Trevor Alan Hatton

Bernhardt Levy Trout

Allan Stuart Myerson

Gregory C Rutledge

Yi Du

Jung-Hoon Chun

Collin Hunter Martin

Kristala Lanett Jones Prather

Nikhil Padhye

Salvatore Mascia

Keith M Forward

Emily Chang

James M B Evans

Ryan Richard Slaughter

Mao Wang

Blair Kathryn Brettmann

James Mb Evans

Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet.

Layer processing for pharmaceuticals

The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.

Microbial production of 3,4-dihydroxybutyrate (3,4-DHBA), 2,3-dihydroxybutyrate (2,3-DHBA) and 3-hydroxybutyrolactone (3-HBL)

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Cambridge, MA, United States of America

Himanshu Hemant Dhamankar