The Uab Research Foundation

Auburn University

Himanshu Gupta

Areus-med, LLC

Thomas S Denney, Jr

Ankur Gupta

Gattadahalli M Anantharamaiah

C Roger White

A computerized information processing method for evaluating blood vessels is provided. The method includes acquiring a series of sequences of measurements, each at different time points in at least one cardiac cycle and at a different point along a blood vessel segment of a subject, generating corresponding profiles, calculating a transfer function for a subsegment between two selected points along a blood flow direction, and based thereon determining the physiological property of the subsegment. The measurements can contain information of blood velocity or blood pressure. A processing device and system implementing the information processing method are also provided. This approach can be used to evaluate arteries or veins and can be applied in screening, diagnosis, or prognosis of a variety of vascular diseases. For example, when combined with MRI scan, this approach can be used for non-invasively diagnosing pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), etc.

Information processing method, device, and system for evaluating blood vessels

A method and system for evaluating physiological properties of a segment of blood vessel is provided. The method includes: acquiring a first measurement and a second measurement respectively at the first point and the second point; obtaining a transfer function configured to produce an output given an input, using the first measurement and the second measurement as the input and the output respectively; and determining the physiological properties of the section of the blood vessel based on the transfer function. The transfer function can be a velocity transfer function based on the blood velocity waveforms, or can be a pressure transfer function based on the blood pressure waveforms. The method and system can be used to non-invasively diagnose PH, COPD, and PA impedance in a pulmonary artery, and to detect a stenosis in a coronary artery.

Method and system for evaluating blood vessel

The present invention provides methods for using synthetic apolipoprotein E (ApoE)-mimicking peptides. Also disclosed are methods for using synthetic apolipoprotein E (ApoE)-mimicking peptides to reduce plasma glucose levels. Methods of using the disclosed apolipoprotein E (ApoE)-mimicking peptides to treat diabetes and diabetic complications are also disclosed.

Synthetic apolipoprotein E mimicking polypeptides and methods of use

Cardiac pacemakers and methods of pacing a heart are disclosed.

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Birmingham, AL, United States of America

Himanshu Gupta