University of Michigan

Accord Biomaterials, Inc.

Himabindu Nandivada

Mark E Meyerhoff

Joerg Lahann

Gary Daniel Smith

Scott I Merz

Jun Ding

Paul Krebsbach

Hsien-Yeh Chen

Thomas Eyster

Sangyeul Hwang

Luis Villa Diaz

Melissa Reynolds

The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix.

Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix

The present invention provides methods and compositions for establishing and maintaining growth of undifferentiated stem cells. In particular, the present invention provides synthetic growth matrices for stem cells, wherein said cells are capable of going through multiple passages while remaining in an undifferentiated state.

Methods and compositions for growth of embryonic stem cells

Reactive polymer coatings that undergo regioselective reactions with target biomolecules are provided. The polymers of the coatings are deposited via chemical vapor deposition and comprise one or more functional groups that exhibit regioselective bonding with a functional group or a target molecule. Such polymers include poly-xylylenes having functional groups such as alkynes or azides. The regioselective bonding of the reactive polymers provide stable immobilization of target molecules and/or ligands and can create biofunctional surfaces having a wide range of applications.

Reactive coatings for regioselective surface modification

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Ann Arbor, MI, United States of America

Himabindu Nandivada