Purdue Research Foundation

Hilkka I Kenttamaa

Benjamin C Owen

James Gerard Perez

Weldon E Vaughn

Ryan Tyler Hilger

Steven C Habicht

David Jesse Borton, Ii

Ravikiran Yerabolu

Jinshan Gao

John Kong

Tiffany Prentice

Zhicheng Jin

Chunfen Jin

Ryan C Shea

A multichannel inlet system for a mass spectrometer includes a plurality of valve assemblies coupled to a manifold, and a pulsed valve driver. The manifold is configured to be connected in fluid connection with an ion trap of the mass spectrometer. Each valve assembly includes a valve and an injection port operably coupled to receive the reagent. The valve has an actuated state in which the valve provides fluid communication between the injection port and the manifold, and an unactuated state in which the valve substantially prevents fluid communication between the injection port and the manifold. The pulsed valve driver is operably connected to receive a pulse signal sequence from a processor, and is configured to generate pulsed valve drive signals for one or more of the valves based on the pulse signal sequence to cause a corresponding one of the valves to be in the actuated state.

Multi-channel pulsed valve inlet system and method

The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (LQIT) mass spectrometers with differentially pumped vacuum chambers.

Differentially pumped dual linear quadrupole ion trap mass spectrometer

The present disclosure provides a novel system and method for evaporating and ionizing compounds comprising an LIAD source and an ionization source that operates at atmospheric pressure. This system is readily adaptable for use with most commercially available mass spectrometers. Ionization sources include Atmospheric Pressure Chemical Ionization sources (APCI) and Atmospheric Pressure Photo Ionization (APPI) sources. The ionization sources are positioned such that the analyte desorbing from the surface of the LIAD is fed into the ion stream produced by the ionization source and ionized analyte and ionized fragments of the analyte are fed into the sample inlet of a mass spectrometer. These systems allow for the mass spectrometric analysis of non-polar compounds that lack readily ionizable functional groups, such as saturated and unsaturated hydrocarbons and compounds with medium to low polarity, as well as hydrocarbon mixtures, such as petroleum.

Laser-induced acoustic desorption/atmospheric pressure chemical ionization of compounds

A high power laser-induced acoustic desorption (LIAD) probe is provided for desorbing neutral molecules from a sample analyte on a target into a mass spectrometer for subsequent ionization.

High power laser induced acoustic desorption probe

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West Lafayette, IN, United States of America

Hilkka I Kenttamaa