The Cleveland Clinic Foundation

Hilel Lewis

Shuvo Roy

Richard A Gross

Aaron J Fleischman

Anthony Calabro

Kiyotaka Fukamachi

Aniq B Darr

Michael K Banbury

Anthony Miniaci

Keiji Kamohara

Marshall Strome

James Chan

Daniel Alam

David Haynes

Daniel P Knott

Alex Melamud

Lee Akst

Aoron J Fleischman

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

Hydroxyphenyl cross-linked macromolecular network and applications thereof

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

An apparatus () for measuring intraocular pressure (IOP) comprises a contact lens () including an inner surface () contoured to a surface portion () of an eye () and a sensor () disposed in the contact lens. The sensor () comprises a contact surface () for making contact with the surface portion () of the eye (). The contact surface () includes an outer non-compliant region () and an inner compliant region () fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor () further comprises a region of conductive material () electrically coupled to the impedance element of the compliant region () and responsive to an external signal for energizing the impedance element so that the IOP may be determined.

Intraocular pressure measurement system including a sensor mounted in a contact lens

An apparatus for measuring intraocular pressure (IOP) comprises a contact lens including an inner surface contoured to a surface portion of an eye and a sensor disposed in the contact lens. The sensor comprises a contact surface for making contact with the surface portion of the eye. The contact surface includes an outer non-compliant region and an inner compliant region fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor further comprises a region of conductive material electrically coupled to the impedance element of the compliant region and responsive to an external signal for energizing the impedance element so that the IOP may be determined.

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Beachwood, OH, United States of America

Hilel Lewis