Genzyme Corporation

American Cyanamid Company

Hildegard M Kramer

Luis Z Avila

Peter K Jarrett

Arthur J Coury

Stephen D Goodrich

C Michael Philbrook

Lewis S Meriwether

John F Traverse

Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.

Polyalkylene glycol viscosity-enhancing polymeric formulations

Hydrogels intended for orthopedic applications, including repair and regeneration of cartilage, bone, joint surfaces and related tissues, must possess greater strength and toughness than hydrogels used in soft tissue repair. A hydrogel formulation is provided which has high strength, toughness, a suitable mechanical modulus and low equilibrium hydration. It may also have controlled porosity or degradation time. It can be made to polymerize in situ with high ('good' to 'excellent') adherence to target tissue or surfaces. A preferred formulation for forming such gels comprises 40 to 80% by weight of a low-molecular weight polar monomer and 30 to 10% of a hydrophilic macromeric crosslinker.

Hydrogels for orthopedic repair

A method for producing heterocyclic aluminum compounds of the formula:

New organo-aluminum antiperspirant compositions

Growing community of inventors

Westport, CT, United States of America

Hildegard M Kramer