Stichting Dienst Landbouwkundig Onderzoek

Id-lelystad, Instituut Voor Dierhouderij En Diergezondheid B.v.

Id-lelystad, Institut Voor Dierhouderij En Diergezondheid B.v.

Boehringer Ingelheim Vetmedica Gmbh

Hilda Elizabeth Smith

Axel Neubauer

Astrid De Greeff

Alaina Ingebritson

The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed againstinfections in pigs. The invention provides a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein said capacity has been reduced by functionally deleting folate transporter (FolT) function. The invention also provides a method to reduce virulence of a bacterium comprising reducing the capacity of said bacterium to transport folate.

Attenuating bacterial virulence by attenuating bacterial folate transport

The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster of Streptococcus suis or a gene or gene fragment derivated thereof. The invention further provides a nucleic acid probe or primer allowing species or serotype-specific detection of Streptococcus suis. The invention also provides a Streptococcus suis antigen and vaccine derived thereof.

vaccines and diagnostic tests

Described areinfections in pigs, vaccines directed against those infections and tests for diagnosinginfections. Provided is an isolated or recombinant nucleic acid encoding a capsular gene cluster ofor a gene or gene fragment derived therefrom. Further provided is a nucleic acid probe or primer allowing species or serotype-specific detection of. Also provided is aantigen and vaccine derived therefrom.

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The invention relates to the field of the diagnosis of and vaccination against Streptococcal infections, and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of acomprising modifying a genomic fragment of the, wherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization into a nucleic acid or fragment thereof.

The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of a, the method comprising modifying a genomic fragment ofwherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization into a nucleic acid or fragment thereof as shown in FIG.

The invention relates toinfection in pigs, vaccines directed against those infections and tests for diagnosinginfections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster ofor a gene or gene fragment derived thereof. The invention further provides a nucleic acid probe or primer allowing species or serotype-specific detection of. The invention also provides aantigen and vaccine derived thereof.

Virulence of streptococci

The invention relates toinfection in pigs, vaccines directed against those infections and tests for diagnosinginfections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster ofor a gene or gene fragment derivated thereof. The invention further provides a nucleic acid probe or primer allowing species or serotype-specific detection of. The invention also provides aantigen and vaccine derived thereof.

The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of acomprising modifying a genomic fragment ofwherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization into a nucleic acid or fragment thereof as shown in.

Growing community of inventors

Lelystad, Netherlands

Hilda Elizabeth Smith