Shionogi Company Limited

Hikozo Iwakura

Shozo Takechi

Sachio Mori

Prostacyclin (PGI.sub.2) analogues represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is lower alkenyl; R.sub.3 and R.sub.4 each is hydrogen or hydroxy-protecting group; R.sub.5 is straight or branched alkyl which may be substituted with heterocycle, straight or branched alkynyl, or cycloalkyl; the wavy line indicates R- or S-configuration, or their mixture; or a salt thereof being used as antithrombotic and antiulcer drugs.

Prostacyclin (PGI.sub.2) analogues

Prostacyclin (PGI.sub.2) analogues represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is alkynyl; R.sub.3 and R.sub.4 each is hydrogen; R.sub.5 is straight or branched alkyl which may be substituted with heterocycle, straight or branched alkynyl, or cycloalkyl; the wavy line indicates R- or S-configuration, or their mixture; or a salt thereof being used as antithrombotic and antiulcer drugs.

Growing community of inventors

Hyogo, Japan

Hikozo Iwakura