Kissei Pharmaceutical Co., Ltd.

Hikaru Suzuki

Takashi Miyagi

Kazuo Shimizu

Kohsuke Ohno

Yasunori Ueno

Yusuke Onda

The present invention provides a new compound which has NKreceptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to carboxymethyl piperidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. Wherein, ring A is a benzene ring or the like; ring B is a pyridine ring or the like; Ris Calkyl or Calkoxy; Rand Rare a hydrogen atom or methyl; and n is an integral number from 0 to 5. 

Carboxymethyl piperidine derivative

A problem of the present invention is to provide a new compound which has NKreceptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof, wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; Ris carboxymethyl or the like; Ris alkyl or the like; Y is 0-2 or the like; U is &#x2014;N(CH)COC(CH)-3,5-bistrifluoromethylphenyl or the like. 

Cyclohexyl pyridine derivative

A problem of the present invention is to provide a new compound which has NKreceptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; Ris carboxymethyl or the like; Ris alkyl or the like; Y is 0-2 or the like; U is &#x2014;N(CH)COC(CH)-3,5-bistrifluoromethylphenyl or the like. 

Growing community of inventors

Azumino, Japan

Hikaru Suzuki