Morinda, Inc.

Masayoshi Ltd.

Hydrox, Inc.

Hifumi Ohishi

Hisanori Tani

Afa Kehaati Palu

Claude Jarakae Jensen

Takashi Hattori

Haruka Arao

Keizou Ohishi

Tetsuya Oishi

Rie Tokuyama

Changfang Zhou

The present invention provides a method of producing a sialooligosaccharide, which comprises: (1) hydrolyzing a sialoglycoprotein by heating at a temperature from 70 to 90&#xb0; C. in an alkaline aqueous solution; and (2) purifying the hydrolysate to obtain the sialooligosaccharide, wherein a weight ratio of sialic acid to hexose contained in the resulting sialooligosaccharide is from 0.5 to 0.9.

Methods of producing sialooligosaccharides and uses thereof

The present disclosure provides an external use composition for skin comprising a tarajo holly leaf extract and a Japanese knotweed leaf extract, a brown algae extract and an egg shell membrane derived peptide (ESM-P) having a molecular mass of 3 kDa or higher. The composition according to the present invention can be used to treat a disease or condition of skin relating to a filaggrin metabolism anomaly, such as atopic dermatitis. The composition according to the present invention can be used specifically for the therapy of atopic dermatitis.

External use composition for skin

The present invention features a unique, natural formulation and method of administering the same to treat and prevent diabetes, or rather advances treatment of diabetes, by providing a naturaceutical composition or treatment formulated with one or more processedproducts as derived from the Indian Mulberry plant. Theis particularly adapted to treat Type II diabetes. Theproduct is preferably a leaf extract, but may also be in the form of a juice, a puree juice, a dietary fiber, or other similar forms and is incorporated into various carriers or naturaceutical compositions suitable for in vivo treatment of a patient. The naturaceutical may also combine other food products into the naturaceutical, such as fruit juices, dietary supplements, vitamins and minerals, and others.

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Preventative and treatment effects of Morinda citrifolia on diabetes and its related conditions

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Tokyo, Japan

Hifumi Ohishi