Symphar S.a.

Ilex Products, Inc.

Other

Smithkline Beecham Corporation

Ilex Oncology Research S.a.

Hieu Trung Phan

Eric Joseph Niesor

Craig Leigh Bentzen

Lan Mong Nguyen

Vinh Van Diep

Raymond Azoulay

Robert John Ife

Yves Guyon-Gellin

Simon Floret

Pierre Maechler

Alexandre Bulla

Lan Nguyen Mong

Jean-Luc Thulliard

Jean Flach

Kyriacos Kalathakis

Lân Mong Nguyen

Harald Eschenhof

Jean-Robert Rossier

Yves Gyon Gellin

Anne Perez

Jean-Luc Thuillard

The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.

Aminodiphosphonate apolipoprotein E modulators

The present invention relates to novel &#x3b2;-substituted-&#x3b2;-aminoethylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

&#x3b2;-substituted &#x3b2;-aminoethyl phosphonate derivatives

The present invention relates to novel &agr;-substituted-&bgr;-aminoethylphosphonate and &agr;-substituted-&bgr;-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

&agr;-Substituted &bgr;-aminoethyl phosphonate derivatives

Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.

Compounds and pharmaceutical compositions containing them

Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity.

Pharmaceutical aminophosphonic acid derivatives

Use of phenol substituted diphosphonates as antineoplastic agents

The present invention relates to novel aminophosphonate derivatives substituted in .alpha. position by phenol groups, of formula (I): ##STR1## in which: X.sup.1, X.sup.2, X.sup.3, R.sup.1, R.sup.2, A, B, Z and n are defined in claim 1, as well as their preparations and the pharmaceutical compositions comprising them.

Substituted aminophosphonate derivatives, process for their preparation

The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.

Method for lowering plasma lipid levels or blood pressure

Phenol substituted gem-diphosphonate derivatives, process for their

2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R.sup.1 and R.sup.2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases. They can be prepared by reacting phosphonating agents with 1,3- dibromopropanes or ditosylates of 1,3-propanediols substituted in position 2. ##STR1## .

Certain 2-substituted 1,3-propylidenediphosphonate derivatives,

Growing community of inventors

Tannay, Switzerland

Hieu Trung Phan