Tokyo Medical and Dental University

Kanagawa Academy of Science and Technology

Mitsubishi Chemical Medience Corporation

On-chip Cellonics Consortium Co., Ltd.

Yasuda, Kenji

Hideyuki Terazono

Kenji Yasuda

Hiroyuki Takei

Tomoyuki Kaneko

Akihiro Hattori

Fumimasa Nomura

Masahito Hayashi

Atsushi Sugiyama

Kentaro Ando

Mamoru Fukushima

Provided is a cell concentration and purification device, having: a function of continuously concentrating cells; a function of then subsequently disposing the cells continuously in a specific region of a channel; a function of simultaneously recognizing, based on an image, the shape and fluorescence emission of each single cell; and a function of recognizing the cells and then separating and purifying the same based on the data relating to the shape and fluorescence emission thereof.

Cell analyzer

The present invention provides a liquid reflux reaction control device comprising:

Liquid reflux high-speed gene amplification device

The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo. A pulsating cell population and hERG-expressing cells (target model cells) are suitably isolated and arranged on a transparent substrate so that the two form gap junctions. The hERG-expressing cells are arranged on transparent electrodes provided on the transparent substrate. The hERG-expressing cells are exposed to a flow of a liquid containing a drug such that the drug acts thereon. The difference between the normal pulsation of hERG-expressing cells and the pulsation when a drug is acting thereon is captured via electric signals obtained from electrodes, and the properties of the change in potential are evaluated.

Model cell chip, apparatus for evaluating drug effect using the model cell chip and method of evaluating drug effect

Growing community of inventors

Kawasaki, Japan

Hideyuki Terazono