Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Honda Giken Kogyo Kabushiki Kaisha

Jfe Steel Corporation

Hideyuki Takahashi

Kiyoshi Watanabe

Yoshio Shimada

Masahiro Ogura

Yoshio Nakamura

Teruo Wakashiro

Shinichi Kitajima

Atsushi Matsubara

Kan Nakaune

Tadayoshi Shiraishi

Kazutomo Sawamura

Kohei Hasegawa

Hideyuki Oki

Junzo Hasegawa

Hiroki Nakamaru

Takehisa Ohashi

Toshinari Shinohara

Hiroyuki Makino

Naoto Yoshimi

Junichiro Hirasawa

Gentaro Takeda

Masato Sasaki

Shigeki Hamaguchi

Hideyuki Tsurumaru

Kenji Takahara

Keita Yonetsu

Hidetoshi Katsuki

Masanori Asada

Satoru Tsuda

A process for preparing optically active (R)-3-chloro-1,2-propanediol, which comprises subjecting (R,S)-3-chloro-1,2-propanediol to the reaction of a microorganism belonging to genus Serratia in a reaction mixture, and then collecting the residual (R)-3-chloro-1,2-propanediol. According to the process of the present invention, (R)-3-chloro-1,2-propanediol can be efficiently prepared starting from low cost (R,S)-3-chloro-1,2-propanediol.

Microbial process for biotransformation to (R)-3-chloro-1,2-propanediol

A process for preparing an optically active 3-chloro-1, 2-propanediol by employing microorganism which can selectively metabolize (R)- or (S)-3-chloro-1,2-propanediol. The decomposition rate of the substrate can be accelerated and the substrate concentration can be increased by adding a compound having SH group to the reaction solution. According to the process of the present invention, the optically active 3-chloro-1,2-propanediol can be easily prepared starting from low-cost (R,S)-3-chloro-1, 2-propanediol.

Process for preparing 3-chloro-1,2-propanediol

A process of manufacturing optically active (S)-1,2-diols, wherein (R)-1,2-diols represented by the general formula [I] ##STR1## (where: R represents a substituted or unsubstituted alkyl group, alkenyl group, aryl group or aralkyl group) or a mixture of diols of the general formula [I] and (S)-1,2-diols represented by the general formula [II] ##STR2## (Where: R represents the same as above) having an opposite configuration to the general formula [I] is subjected to the action of a microorganism capable of selectively metabolizing the diols of the general formula [I], or capable of converting the diols of the general formula [I] into the diols of the general formula [II], or having the both capabilities, and the formed and accumulated (S)-1,2-diols of the general formula [II] is collected. According to the present invention, optically active (S)-1,2-diols can be produced commercially and advantageously.

Manufacturing method of optically-active 1,2-diols

A process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)-indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetrically hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [II*] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [II*] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [I*], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*]. According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.

Process for preparing optically active indoline-2-carboxylic acid

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Kakogawa, Japan

Hideyuki Takahashi