Shiseido Company, Limited

Senju Pharmaceutical Co., Ltd.

Nihon Shokuhin Kako Co., Ltd.

Hideyuki Sumiyoshi

Hajime Matsuda

Yohei Hamano

Yoshikazu Soyama

Kenzo Ito

Takashi Minami

Noriko Tomita

Akio Nasu

Takayuki Miyazaki

Takashi Matsumoto

Nobuyuki Nakamura

Mikio Yamamoto

A cholesterol ester clathrate comprising a cholesterol ester included in a hydroxyalkylated cyclodextrin; a hydrous composition comprising a hydroxyalkylated cyclodextrin, a cholesterol ester and water; a hydrous composition comprising a hydroxyalkylated cyclodextrin, a cholesterol ester, a hydrous stabilizer, and water; a hydrous composition comprising a hydroxyalkylated cyclodextrin, a cholesterol ester, a clay mineral, and water; cosmetics containing these hydrous compositions; and process for the preparation thereof. The clathrate exhibits an emulsifying effect in itself. Further, the hydrous compositions are excellent in water-holding capacity and are improved in hydration properties and separation stability at a high temperature.

Cholesterol ester clathrate, water-holding composition, hydrous compositions, cosmetics containing the same, and process for the preparation thereof

The invention provides a clathrate comprising a cyclodextrin or hydroxyalkylated cyclodextrin and, as included therein, dl-.alpha.-tocopheryl L-ascorbyl phosphate. In another aspect, the invention provides a dermal composition for external use, particularly a cosmetic composition. The composition is characterized by reduced foam production in aqueous solution and good stability against light.

Tocopheryl ascorbyl phosphate-cyclodextrin clathrate and a topical

Cholesterol ester clathrate, water-holding composition, hydrous

A method for recovering cyclodextrin, comprising passing an aqueous solution containing an inclusion compound of cyclodextrin with a guest compound, through a non-polar, high-porous hydrophobic adsorption resin, which is the cross-linked copolymer of styrene with divinylbenzene, comprised of styrene as a basic skeleton, to cause the adsorption resin to preferentially adsorb the guest compound for its removal. The method enables economical recovery of cyclodextrin in a good efficiency and at a high purity from inclusion compounds of cyclodextrin with guest compounds such as cholesterol and other lipids.

Method for recovering cyclodextrin

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Fuji, Japan

Hideyuki Sumiyoshi