Smithkline Beecham Corporation

Glaxosmithkline LLC

Hideyuki Sato

Jun Tang

Masaichi Hasegawa

Yoshiaki Washio

James Marvin Veal

Jerry Leroy Adams

Mui Cheung

Philip Anthony Harris

Shinichiro Matsunaga

Domingos J Silva

Deborah Lynne Bryan

Yanhong Feng

Yasushi Miyazaki

Naohiko Nishigaki

Marcus Semones

Yutaka Maeda

Satoru Ida

Jean-Philippe Rocher

Kazuya Kano

Rob I West

Mio Takada

Masato Nakano

This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.

Chemical compounds

This invention relates to newly identified inhibitors of kinases for treating various disorders.

Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof

Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Growing community of inventors

Tsukuba, Japan

Hideyuki Sato