Kyowa Hakko Kirin Co., Limited

Kyowa Kirin Co., Ltd.

Hideyuki Onodera

Tsutomu Agatsuma

Masahiro Ikeda

Kenji Uchida

Shinpei Yamaguchi

Susumu Iwamoto

Kyoichiro Iida

Shimpei Yamaguchi

Setsuya Sasho

Yumiko Uochi

Kazuhiro Hibino

Masumi Murakami

Makoto Suzuki

Kouji Baba

An object of the present invention is to provide a novel IL-2 variant which has improved selectivity for IL-2Rand selectively activates Tregs. The present invention relates to an IL-2 variant, a method for producing the IL-2 variant, a composition and a therapeutic agent for an immune disease, comprising the IL-2 variant, a method for increasing selectivity of IL-2 for IL-2Rαβγ, a method for improving an affinity of IL-2 for an IL-2Rα subunit, a method of reducing an affinity of IL-2 for at least one of an IL-2Rβ subunit and an IL-2Rγ subunit, and a method for selectively activating regulatory T cells.

IL-2 variant

A 4,6-hexadecadiene-2,4-dicarboxylic acid derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof, each of which has an anti-tumor activity, and the like, are provided. [wherein, Rrepresents hydroxy, &#x2014;OR(wherein Rrepresents optionally substituted lower alkyl or an optionally substituted aliphatic heterocyclic group), or &#x2014;NRR(wherein Rand Rmay be the same or different, and each represents a hydrogen atom or optionally substituted lower alkyl) and Rrepresents hydroxy or &#x2014;OR(wherein Rrepresents optionally substituted lower alkyl or optionally substituted aralkyl)].

4,6-hexadecadiene-2,4-dicarboxylic acid derivative

The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xand Xare the same or different, and represent a bond or the like; R, R, R, R, Rand Rare the same or different, and represent a hydrogen atom or the like; Rand Rare the same or different, and represent a hydrogen atom or the like; Rrepresents a hydrogen atom or the like; Rand Rtogether represent a bond or the like; and Rrepresents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof. 

Sterol derivative

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Chiyoda-ku, Japan

Hideyuki Onodera