Kissei Pharmaceutical Co., Ltd.

Hideyuki Muranaka

Tetsuro Tamai

Nobuyuki Tanaka

Harunobu Mukaiyama

Masuo Akahane

Masaaki Sato

Akihito Hirabayashi

Ken Kikuchi

Satoshi Akahane

Takehiro Ishikawa

Makio Kitazawa

Junichi Kobayashi

Tetsuya Nakamura

Kosuke Okazaki

Hiroaki Kobayashi

Masaru Saito

Yuichiro Kai

Tatsuhiro Kondo

Tomonaga Ozawa

Ritsu Suzuki

Masayuki Isaji

Nobuhiko Fushimi

Kazuo Shimizu

Shigeru Yonekubo

Hirotaka Teranishi

Hiroaki Shiohara

Fumiaki Ito

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein Rand Rare each hydrogen or lower alkyl; R, R, Rand Rare each hydrogen, halogen, lower alkyl or lower alkoxy; Rand Rare each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; Ris &#x2014;C(O)&#x2014;R, -A-C(O)&#x2014;R, &#x2014;O-A-C(O)&#x2014;Ror a tetrazol-5-yl group, which exhibit potent and selective &#x3b2;3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof

The present invention provides fused heterocyclic derivatives represented by the general formula: wherein Rrepresents H, halogen, OH, etc.; Rrepresents H, halogen or an alkyl group; Rand Rrepresent H, OH, halogen, etc.; Q represents alkylene, etc.; ring A represents aryl or heteroaryl; and G represents or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.

Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof

The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein Ris hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R, Rand Ris independently hydrogen, halogen, lower alkyl or lower alkoxy; Ris hydrogen or lower alkyl; Ris hydrogen, halogen, lower alkyl, lower alkoxy, etc; Ris &#x2014;COR, -A-COR, &#x2014;O-A-COR, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, &#x2014;OCH&#x2014;, etc, which exhibit potent and selective &#x3b2;3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Amino alcohol derivatives, medicinal composition containing the same, and use of these

2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same

2-Methylpropionic acid derivatives and medicinal compositions containing the same

Phenoxyacetic acid derivatives and medicinal compositions containing the same

Aminoethylphenoxyacetic acid derivatives and drugs for pain remission and calculi removal promotion in urinary lithiasis

Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same

3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives

3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives

Phenylethanolaminotetralincarboxamide derivatives

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Nagano, Japan

Hideyuki Muranaka