Chiba University

Fujikura Kasei Co., Ltd.

Hideyuki Kuroda

Go Tomiyoshi

Takaki Hiwasa

Rika Nakamura

Naokatsu Saeki

Masaki Takiguchi

Toshio Machida

Saeki Naokatsu

The present inventors have surprisingly found that a deoxyhypusine synthase (DHPS) gene, which was previously reported to correlate with prostate cancer and cervical cancer, is highly responsive to arteriosclerosis or digestive system cancer, whereby the gene can be used as a desired marker for arteriosclerosis or digestive system cancer. The present invention has been accomplished on the basis of this finding. Specifically, the present invention provides a method for determining arteriosclerosis or digestive system cancer, which method includes detecting expression of a deoxyhypusine synthase gene in a test sample (preferably a blood sample), and determining arteriosclerosis or digestive system cancer of a test subject from which the test sample has been obtained, on the basis of an increase in the gene expression as an index.

Arteriosclerosis and cancer detection method using deoxyhypusine synthase gene as indicator

Objects of the present invention are to find a marker by which progression of arteriosclerosis can be directly grasped, to thereby provide motivation for prevention or treatment of arteriosclerosis itself, and to provide means for accurately grasping condition of arteriosclerosis-related disease including arteriosclerotic disease. The invention provides a method for acquiring data on progression of arteriosclerosis, the method including determining a level of an antibody against SH3BP5 protein or a part thereof in a body fluid sample collected from a biological body, and a data acquisition kit for performing the data acquisition method.

Method of detecting arteriosclerosis

Disclosed are: a polypeptide marker for diagnosing arteriosclerosis; a gene marker for diagnosing arteriosclerosis; an antibody; a probe for detecting an arteriosclerosis marker gene; a DNA microarray or a DNA chip for detecting an arteriosclerosis marker gene; a method for detecting arteriosclerosis; and a kit for diagnosing arteriosclerosis; with which an arteriosclerotic lesion can be detected with much improved accuracy. Specifically disclosed are: a polypeptide marker for diagnosing arteriosclerosis, which comprises a polypeptide having an amino acid sequence set forth in any one of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, and 35 of the Sequence Listing, or a partial amino acid sequence thereof; a gene which encodes the amino acid sequence; a probe for detecting the gene; a DNA microarray or a DNA chip comprising the probe; an antibody bindable to the polypeptide as an antigen; a kit comprising any one of the above-mentioned items; and a method for detecting arteriosclerosis by using any one of the above-mentioned items.

Polypeptide marker for diagnosis of arteriosclerosis, method for detection of arteriosclerosis by using the maker or the like, and kit for diagnosis of arteriosclerosis

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Kuki, Japan

Hideyuki Kuroda