Kyorin Pharmaceutical Co., Ltd.

Matsushita Electric Industrial Co., Ltd.

Hideyuki Fukuda

Yasumichi Fukuda

Seigo Suzue

Yoshikazu Asahina

Keiji Hirai

Masanori Takadoi

Yasuaki Namura

Masaya Takei

Tatsuhiro Saito

Taro Sato

Hiroyuki Ebisu

Haruaki Kurasaki

Kikoh Obi

To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): or a pharmaceutically acceptable addition salt thereof.

Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position

A controllable-frequency oscillator has a first portion for generating a signal having a controllable frequency. The controllable-frequency oscillator has a second portion for controlling the frequency of the signal generated by the first portion in response to a first control signal. The controllable-frequency oscillator has a third portion for controlling the frequency of the signal generated by the first portion in response to a second control signal separate from the first control signal.

Oscillator circuit with first and second frequency control elements

Novel cephem compounds represented by a formula [I] and pharmacologically admissible salts or capable of physiologically hydrolyzable nontoxic esters thereof are disclosed. ##STR1## [wherein R.sup.1 indicates a straight-chain or branched lower alkyl group, which may be substituted by carboxyl group which may be protected, trityl group, hydrogen atom or fluorine-substituted lower alkyl group, R.sup.2 indicates a hydrogen atom, metal atom, protective group for carboxyl group or ester residue producible hydrolyzable ester in vivo, R.sup.3, R.sup.4, R.sup.5 and R.sup.6, which may be identical or different, indicate hydrogen atoms, halogen atoms, straight-chain or branched lower alkyl groups, which may be substituted, mercapto groups, which may be substituted, lower alkylamino groups, hydroxyl groups, which may be protected, lower alkoxy groups, lower alkanoyl groups, lower alkoxycarbonyl groups, or lower alkylenedioxy groups, which may be substituted, being maybe formed with R.sup.3 and R.sup.4, R.sup.7 indicates a hydrogen atom, cyano group, halogen atom or COOR.sup.8 (R.sup.8 is hydrogen or lower alkyl group), R.sup.9 indicates an amino group, which may be protected, Z indicates N or CH, and n indicates 0 or 1]. Preparation processes for them and antibacterial agents containing them as effective ingredients are also claimed.

Cephem compounds, and antibacterial agents

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Tokyo, Japan

Hideyuki Fukuda