Kanebo, Limited

Kao Corporation

Kanebo Cosmetics Inc.

Hideyo Uchiwa

Masaki Yoshida

Takeshi Ikemoto

Akinori Haratake

Hiromi Minamino

Shunsuke Yamazaki

Toshio Horikoshi

Umeji Murakami

Sachiyo Hirotsu

Kenichi Sugimoto

Junichi Matsui

Motoi Hayase

Junichiro Hiraoka

Keiko Hashimoto

Toshihiro Usui

Shigeru Igarashi

Makoto Hirano

Minoru Ohta

Takusaburou Ebina

The present invention provides a method for enhancing epidermal permeability barrier function of the aged skin, which includes the step of externally administering to the aged skin an amount of a fumaric acid diester derivative expressed by the following general formula (1) as an active ingredient wherein Rrepresents a Calkylene group; Rand Reach represents a linear or branched Calkyl group; and n is an integer of 2 to 5.

Skin external agents and drugs

Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein Rrepresents Calkylene; Rand Rrepresent each liner or branched Calkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

Hair coloring composition comprising anti-hair antibodies immobilized on

Hair treatment composition and hair care product, both containing

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Odawara, Japan

Hideyo Uchiwa